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http://hdl.handle.net/10201/19341
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Goussia, A.C. | es |
dc.contributor.author | Loachim, E. | es |
dc.contributor.author | Agnantis, N.J. | - |
dc.contributor.author | Mahera, M. | - |
dc.contributor.author | Tsianos, E.V. | - |
dc.date.accessioned | 2011-02-22T11:22:01Z | - |
dc.date.available | 2011-02-22T11:22:01Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19341 | - |
dc.description.abstract | Immunostaining for bcl-2 protein was performed in 27 colorectal adenomas and 108 colorectal adenocarcinomas. The aim of the study was to determine bcl-2 expression in correlation with p53, mdm-2 and Rb expression, with proliferation indices (Ki-67-LI, PCNALI) as well as with conventional clinicopathological variables. A higher proportion of adenomas (30.8%) than carcinomas (16.7%) expressed bcl-2 and conversely, a lower proportion of adenomas (7.4%) than carcinomas expressed p53 (57.1 %), the difference being statistically significant (p<0.0001). No correlation of bcl-2 expression with p53 expression (parallel or inverse) as well as with the other parameters studied was observed in any tumour. The bcl-2+/p53- subgroup of cancers showed a trend for correlation with negative lymph node status. Our data suggest, that bcl-2 expression may be involved in the early phase of colorectal carcinogenesis regardless of p53 status, while p53 function may be involved in a late stage of the adenoma-carcinoma sequence. P53 is apparently not involved in the regulation of apoptosis in the colorectal neoplasias or perhaps bcl-2 expression, as an early event in colorectal tumours, may occur before changes of p53 take place. Tumours with bcl-2+/p53- immunophenotype are frequently associated with negative lymph node status and seem to have a less aggressive behavior. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | p53 | es |
dc.subject | Colorectal tumours | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Bcl-2 expression in colorectal tumours. Correlation with p53, mdm-2, Rb proteins and proliferation indices | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 3 (2000) |
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Fichero | Descripción | Tamaño | Formato | |
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Bcl2 expression in colorectal tumours. Correlation with p53 mdm2 Rb proteins and proliferation indices.pdf | 1,35 MB | Adobe PDF | ![]() Visualizar/Abrir |
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