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Título: | Expression of galectin-l and -3 and of accessible binding sites during murine hair cycle |
Fecha de publicación: | 2000 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.5 - Piel. Dermatología clínica |
Palabras clave: | Galectins Hair cycle |
Resumen: | Although protein-carbohydrate interactions are supposed to play key roles in cell adhesion, signalling and growth control. Their exact role in skin physiology has only recently been investigated. The endogenous lectins galectin-l and galectin-3 have been identified in skin including hair follicles. Here, we analyzed the expression and distribution of these galectins and their binding sites in C57BL/6 mice during hair cycle. The expression of galectin-l and galectin-3 binding sites was found to be predominantly hair cycledependent showing some overlapping to the expression of galectin-l and -3. The outer root sheath (ORS) expressed galectin-l binding sites during anagen IV to V1 and in early catagen, whereas galectin-l was expressed from early anagen to late catagen. The ORS expressed galectin-3 binding sites during catagen transition corresponding to a galectin-3 expression during anagen V and catagen. The innermost layer of the ORS expressed galectin-3 binding sites during anagen V1 until catagen VIII, but galectin-3 during anagen I11 to IV and catagen. The inner root sheath (IRS) expressed galectin-3 binding sites only in anagen IV but missed expression of any of the two galectins. The matrix cells expressed galectin-3 binding sites in catagen 11-111 as well as galectin-3 during anagen V to catagen IV. The present study provides the first evidence for a cyclerelated expression of both galectin-l and -3 and their binding sites during murine hair cycle. |
Autor/es principal/es: | Wollina, U. Lange, D. Paus, R. Burchert, M. Gabius, H.J. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19269 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.15, nº 1 (2000) |
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Expression of galectinl and 3 and of accessible binding sites during murine hair cycle.pdf | 5,85 MB | Adobe PDF | Visualizar/Abrir |
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