Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/18990

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dc.contributor.authorTuccari, G.es
dc.contributor.authorRossiello, R.es
dc.contributor.authorBarresi, G.-
dc.date.accessioned2011-02-22T10:41:59Z-
dc.date.available2011-02-22T10:41:59Z-
dc.date.issued1997-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18990-
dc.description.abstractBy immunohistochemistry, the presence of major iron-binding proteins (lactoferrin, transferrin, ferritin) has been investigated in adenocarcinomas (27 cases), adenosquamous carcinoma (1 case), undifferentiated sarcomatoid carcinoma (1 case) and mucinous adenocarcinomas (3 cases) of the gallbladder; 10 samples of chronic lithyasic cholecystitis, 4 adenomyomas and 6 tubulo-villous adenomas have also been studied. In a variable share of adenocarcinomas, a positive immunoreactivity for iron-binding antisera was encountered in the cytoplasm, while tubulo-villous adenomas, adenomyomas and the normal epithelium of the gallbladder were generally unreactive. In carcinomatous lesions, the staining intensity was variable between different cases or individual tumour cells. The production of these iron-binding proteins in the gallbladder carcinoma in itself could be related to a greater availability of iron for metabolic processes in the neoplastic cell; alternatively, the cytoplasmic localization of these substances in carcinomatous elements may be a consequence of a defective or impaired function of iron-binding receptors with a modified degree of transmembranous iron transfer.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectLactoferrines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titlelron binding proteins in gallbladder carcinomas An immunocytochemical investigationes
dc.typeinfo:eu-repo/semantics/articlees
Appears in Collections:Vol.12, nº 3 (1997)

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