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Título: | The microanatomy of calcium stores in human neutrophils, Relationship of structure to function |
Fecha de publicación: | 1997 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Neutrophils Calcium stores |
Resumen: | As changes in cytosoiic free ca2+ play key roles in coupling responses in neutrophils, it is important to locate and identify ca2+ storage sites within these cells. Here, recent data is presented which highlights the functional link between rnicroanatomical structure and cell signailing function. Fluorescent opticai probes for cytosolic free ca2+ have been used, together with organelle specific markers. We present evidence from conventional fluorescence microscopy, together with ratiometric and confocal laser scanning fluorescence microscopy, which pin-points two celiular locations for ca2+ within the neutrophil; one within the nuclear lobes, and the other towards the ceii periphery. Knowledge of these two locations provides a clear insight into how signailing in this cell type is regulated and provides a framework for explaining how specific stimuli act to produce specific responses. |
Autor/es principal/es: | Pettit, E.J. Davies, E.V. Hallett, M.B. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18935 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.12, nº 2 (1997) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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The microanatomy of calcium stores in human neutrophils Relationship of structure to function.pdf | 7,73 MB | Adobe PDF | Visualizar/Abrir |
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