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Título: | Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease |
Fecha de publicación: | 1997 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso |
Palabras clave: | Parkinson's disease Apoptosis |
Resumen: | Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive cell loss confined mostly to dopaminergic neurons of the substantia nigra. Several factors, including oxidative stress, and decreased activity of complex 1 mitochondrial respiratory chain, are involved in the degenerative process. Yet, the underlying mechanisms leading to dopaminergic cell loss remain elusive. Morphological assessrnent for different modes of cell death: apoptosis, necrosis or autophagic degeneration, can contribute significantly to the understanding of this neurona1 loss. Ultrastructural examination revealed characteristics of apoptosis and autophagic degeneration in melanized neurons of the substantia nigra in PD patients. The results suggest that even at the final stage of the disease, the dopaminergic neurons are undergoing active process of cell death. |
Autor/es principal/es: | Anglade, P. Vyas, S. Javoy-Agid, F. Herrero Ezquerro, María Trinidad Michel, P.P. Marquez, J. Mouatt-Prigent, A. Ruberg, M. Hirsch, E.C. Agid, Y. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18924 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.12, nº 1 (1997) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Apoptosis and autophagy in nigral neurons of patients with Parkinsons disease.pdf | 4,05 MB | Adobe PDF | Visualizar/Abrir |
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