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http://hdl.handle.net/10201/18923
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | vera-Sempere, F.J. | es |
dc.contributor.author | Burgos, J.S. | es |
dc.contributor.author | Botella, M.S. | - |
dc.contributor.author | Morera, C. | - |
dc.date.accessioned | 2011-02-22T10:40:40Z | - |
dc.date.available | 2011-02-22T10:40:40Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/18923 | - |
dc.description.abstract | Expression of Bcl-2 is associated with inhibition of apoptosis and extension of cell survival. In vitro Bcl-2 protein expression is up-regulated by the EBV-latency associated antigen latent membrane protein (LMP-1). We have investigated the relationship between the presence of EBV-DNA screened by means of sensitive nested-PCR, nasopharyngeal carcinoma (NPC) histological types according to two different schemata (WHO and Micheau classifications) and Bcl-2-124 immunohistochemical expression in 55 biopsy samples of NPC. EBV genome was detected in 100% of samples with sufficient DNA quality to support the previous view that al1 types of NPC are variants of EBV-infected neoplasia. Bcl-2 was observed in the basa1 layer of normal nasopharyngeal mucosa and also at cytoplasmic level in 42 of 55 (76.4%) NPC cases. Mitotic neoplastic cells usually showed strong cytoplasmic and chromosomal staining, a finding not well referred to previously. Bcl-2 expression was significantly associated (p<0.05) to undifferentiated NPC (UNPC) when a histological classification with only two major microscopical types was applied. No close correlations were found between the presence of EBV-DNA, NPC location, clinical stage and age or sex of the patients in relation to Bcl-2 positive expression. However, when comparing Bcl-2 expression and known survival mean of the patients, significant differences were observed (p<0.001) so that mean survivals were 3 1.1, 24.4, 52.2 and 54.1 months respectively for NPC patients with -, +, ++ and +++ Bcl-2 immunoreactivity. Nevertheless this better clinical outcome in Bcl-2 NPC positive cases may depend on the histological type due to close relationship with UNPC. Only studies of larger series with long-term follow-up and multivariate analyses may document whether Bcl-2 expression is an independent prognostic marker in the evolution of NPC patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Nasopharyngeal carcinoma | es |
dc.subject | Prognosis | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio | es |
dc.title | lmmunohistochemical expression of Bcl-2 oncoprotein in EBV-associated nasopharyngeal carcinoma correlated to histological type and survival | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.12, nº 1 (1997) |
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Fichero | Descripción | Tamaño | Formato | |
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lmmunohistochemical expression of Bcl2 oncoprotein in EBVassociated nasopharyngeal carcinoma correlated to histological type and survival.pdf | 2,22 MB | Adobe PDF | ![]() Visualizar/Abrir |
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