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Título: Effects of pneumadin (PNM) on the adrenal glands. 5.Potent stimulating action of PNM on adrenocortical growth of dexamethasone-administered rats
Fecha de publicación: 1996
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Pneumadin
Adrenal cortex
Resumen: Pneumadin (PNM) is a biologically active decapeptide, originally isolated from mammalian lungs, that has been previously found to acutely stimulate pituitary-adrenocortical axis in rats. The effects of 2-day PNM administration on the atrophic adrenal cortices of rats treated for 8 days with dexamethasone (DX) were investigated. PNM significantly raised adrenal weight and the average volume of adrenocortical cells. The decapeptide strikingly increased ACTH plasma concentration; however, the blood levels of aldosterone and corticosterone, as well as steroid output by adrenal quarters were not apparently affected. In light of these findings the following conclusions can be drawn: (i) PNM enhances the growth of adrenal cortex in DXadministered rats by a mechanism involving the stimulation of ACTH release; and (ii) PNM treatment is probably too short to allow DX-atrophied adrenocortical cells to re-acquire al1 their differentiated secretory capacities.
Autor/es principal/es: Markowska, A.
Macchi, C.
Nussdorfer, G.G.
Malendowicz, L.K.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18865
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 3
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.11, nº 3 (1996)

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