Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/18865
Twittear
Título: | Effects of pneumadin (PNM) on the adrenal glands. 5.Potent stimulating action of PNM on adrenocortical growth of dexamethasone-administered rats |
Fecha de publicación: | 1996 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Pneumadin Adrenal cortex |
Resumen: | Pneumadin (PNM) is a biologically active decapeptide, originally isolated from mammalian lungs, that has been previously found to acutely stimulate pituitary-adrenocortical axis in rats. The effects of 2-day PNM administration on the atrophic adrenal cortices of rats treated for 8 days with dexamethasone (DX) were investigated. PNM significantly raised adrenal weight and the average volume of adrenocortical cells. The decapeptide strikingly increased ACTH plasma concentration; however, the blood levels of aldosterone and corticosterone, as well as steroid output by adrenal quarters were not apparently affected. In light of these findings the following conclusions can be drawn: (i) PNM enhances the growth of adrenal cortex in DXadministered rats by a mechanism involving the stimulation of ACTH release; and (ii) PNM treatment is probably too short to allow DX-atrophied adrenocortical cells to re-acquire al1 their differentiated secretory capacities. |
Autor/es principal/es: | Markowska, A. Macchi, C. Nussdorfer, G.G. Malendowicz, L.K. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18865 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 3 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.11, nº 3 (1996) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Effects of pneumadin PNM on the adrenal glands. 5.Potent stimulating action of PNM on adrenocortical growth of dexamethasoneadministered rats.pdf | 1,77 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.