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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Markowska, A. | es |
dc.contributor.author | Macchi, C. | es |
dc.contributor.author | Nussdorfer, G.G. | - |
dc.contributor.author | Malendowicz, L.K. | - |
dc.date.accessioned | 2011-02-22T10:32:57Z | - |
dc.date.available | 2011-02-22T10:32:57Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/18865 | - |
dc.description.abstract | Pneumadin (PNM) is a biologically active decapeptide, originally isolated from mammalian lungs, that has been previously found to acutely stimulate pituitary-adrenocortical axis in rats. The effects of 2-day PNM administration on the atrophic adrenal cortices of rats treated for 8 days with dexamethasone (DX) were investigated. PNM significantly raised adrenal weight and the average volume of adrenocortical cells. The decapeptide strikingly increased ACTH plasma concentration; however, the blood levels of aldosterone and corticosterone, as well as steroid output by adrenal quarters were not apparently affected. In light of these findings the following conclusions can be drawn: (i) PNM enhances the growth of adrenal cortex in DXadministered rats by a mechanism involving the stimulation of ACTH release; and (ii) PNM treatment is probably too short to allow DX-atrophied adrenocortical cells to re-acquire al1 their differentiated secretory capacities. | es |
dc.format | application/pdf | es |
dc.format.extent | 3 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Pneumadin | es |
dc.subject | Adrenal cortex | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Effects of pneumadin (PNM) on the adrenal glands. 5.Potent stimulating action of PNM on adrenocortical growth of dexamethasone-administered rats | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.11, nº 3 (1996) |
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Fichero | Descripción | Tamaño | Formato | |
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Effects of pneumadin PNM on the adrenal glands. 5.Potent stimulating action of PNM on adrenocortical growth of dexamethasoneadministered rats.pdf | 1,77 MB | Adobe PDF | Visualizar/Abrir |
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