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Título: | lntegrin expression on epiphyseal mouse chondrocytes in monolayer culture |
Fecha de publicación: | 1995 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomía |
Palabras clave: | Chondrocytes Immunoelectronmicroscopy |
Resumen: | The expression of al-, a3-, av- and a5B1- integrins and their specific ligand binding were investigated in monolayer cultures of chondrocytes from 17-day-old mouse embryos using morphological and immunomorphological methods. After a 1-day culture period av-, a3- and a5B1-integrins were observed on these cells. Immunoelectronmicroscopic investigation revealed localization predominantly in the contact areas with extracellular structures on the cell surface. alintegrin could not be demonstrated on chondrocytes. After a 5-day culture period the number of fibroblastlike cells with a l - , av- and a5B1-integrins had increased. a3-integrin was hardly recognizable on these cells. Collagen type 1 and fibronectin could be shown as ligands on the cell surface. The number of chondrocytes with collagen type 11 on their surface continuously decreased. a3-integrin is obviously responsible for the binding of collagen type 11, and al-integrin for the binding of collagen type 1. Therefore, it can be concluded that the changes of chondrocytes to fibroblast- like cells in monolayer culture are accompanied by changes of integrin genes. |
Autor/es principal/es: | Shakibaei, M. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18728 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.10, nº 2 (1995) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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lntegrin expression on epiphyseal mouse chondrocytes in monolayer culture.pdf | 6,21 MB | Adobe PDF | Visualizar/Abrir |
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