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Título: | Effects of various antineoplastic agents on-2 |
Fecha de publicación: | 1995 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Melphalan CCNU |
Resumen: | An established human melanoma cell line was treated with severa1 concentrations of three antineoplastic drugs: melphalan (0.01 6, 0.032, 0.16 pn), CCNU (1- (2-chloroethy1)-3-cyclohexyl1-- nitrosourea) (0.04, 0.21, 0.42 pM) and 4-OHA (4-hydroxyanisole) (4.01 x 1 0-4, 1 . 2 0~1 0 -2~.,4 ~ pM), and the effects on cell growth and viability were compared. 24 hours after treatment, 4-OHA ( 1 ~ ~ ~ = 2 . 4 ~ 1 0 - ~ pM) was more cytotoxic than melphalan (ID50=0.016 pM) and CCNU (ID50=0.21 pM). However. after 96 hours exposure, the most effective drug was CCNU (growth rate = -1.277), which caused the death of the culture. This was followed by melphalan (growth rate = - 1.024) and finally 4-OHA (growth rate= -0.69). Similar ultrastructural cell injuries were observed after the use of the three drugs: the dilation of endoplasmic reticulum vesicles and the nuclear membrane; mitochondria swelling; and the existence of lamellar structures and cytoplasmic vacuoles. |
Autor/es principal/es: | García Reverte, Juana María Bernabeu-Esclapez, A. Muñoz Ramos, J. Vicente Ortega, Vicente Canteras Jordana, Manuel |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18707 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.10, nº 1 (1995) |
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Fichero | Descripción | Tamaño | Formato | |
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Effects of various antineoplastic agents on2.pdf | 578,74 kB | Adobe PDF | Visualizar/Abrir |
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