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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | García Reverte, Juana María | es |
dc.contributor.author | Bernabeu-Esclapez, A. | es |
dc.contributor.author | Muñoz Ramos, J. | - |
dc.contributor.author | Vicente Ortega, Vicente | - |
dc.contributor.author | Canteras Jordana, Manuel | - |
dc.date.accessioned | 2011-02-22T10:29:36Z | - |
dc.date.available | 2011-02-22T10:29:36Z | - |
dc.date.issued | 1995 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/18707 | - |
dc.description.abstract | An established human melanoma cell line was treated with severa1 concentrations of three antineoplastic drugs: melphalan (0.01 6, 0.032, 0.16 pn), CCNU (1- (2-chloroethy1)-3-cyclohexyl1-- nitrosourea) (0.04, 0.21, 0.42 pM) and 4-OHA (4-hydroxyanisole) (4.01 x 1 0-4, 1 . 2 0~1 0 -2~.,4 ~ pM), and the effects on cell growth and viability were compared. 24 hours after treatment, 4-OHA ( 1 ~ ~ ~ = 2 . 4 ~ 1 0 - ~ pM) was more cytotoxic than melphalan (ID50=0.016 pM) and CCNU (ID50=0.21 pM). However. after 96 hours exposure, the most effective drug was CCNU (growth rate = -1.277), which caused the death of the culture. This was followed by melphalan (growth rate = - 1.024) and finally 4-OHA (growth rate= -0.69). Similar ultrastructural cell injuries were observed after the use of the three drugs: the dilation of endoplasmic reticulum vesicles and the nuclear membrane; mitochondria swelling; and the existence of lamellar structures and cytoplasmic vacuoles. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Melphalan | es |
dc.subject | CCNU | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Effects of various antineoplastic agents on-2 | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.10, nº 1 (1995) |
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Fichero | Descripción | Tamaño | Formato | |
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Effects of various antineoplastic agents on2.pdf | 578,74 kB | Adobe PDF | Visualizar/Abrir |
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