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Título: Different effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortex
Fecha de publicación: 1994
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Neurotensin
Neuromedin N
Resumen: Evidence indicates that neurotensin (NT) and neuromedin-N (NMN) exerts an adrenocorticotropic effect in the rat. The present study aimed to investigate whether these neuropeptides are able to stimulate the proliferation of rat adrenocortical cells in vivo and to compare their mode of action. Adrenocortical proliferative activity was assessed by the metaphasearrest technique and metaphases were counted per medulla-containing adrenal section. A bolus administration of NT (3 pglrat) resulted in a significant increase in the number of metaphases in both zona fasciculata and the entire cortex, an effect observed 48 h after the in.jection. The administration of NMN (3 yglrat) induced a notable rise in the number of metaphases in the zona fasciculata and the entire cortex within 12 h, followed by a subsequent drop after 24 h and a return to normal values at 48 h. These findings indicate that NT and NMN enhance rat adrenal growth in vivo acting via different mediators.
Autor/es principal/es: Markowska, A.
Nussdorfer, G.G.
Malendowicz, L.K.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18526
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 4
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 9, nº 3 (1994)

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