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dc.contributor.authorMarkowska, A.es_ES
dc.contributor.authorNussdorfer, G.G.es_ES
dc.contributor.authorMalendowicz, L.K.-
dc.description.abstractEvidence indicates that neurotensin (NT) and neuromedin-N (NMN) exerts an adrenocorticotropic effect in the rat. The present study aimed to investigate whether these neuropeptides are able to stimulate the proliferation of rat adrenocortical cells in vivo and to compare their mode of action. Adrenocortical proliferative activity was assessed by the metaphasearrest technique and metaphases were counted per medulla-containing adrenal section. A bolus administration of NT (3 pglrat) resulted in a significant increase in the number of metaphases in both zona fasciculata and the entire cortex, an effect observed 48 h after the in.jection. The administration of NMN (3 yglrat) induced a notable rise in the number of metaphases in the zona fasciculata and the entire cortex within 12 h, followed by a subsequent drop after 24 h and a return to normal values at 48 h. These findings indicate that NT and NMN enhance rat adrenal growth in vivo acting via different mediators.es_ES
dc.publisherMurcia : F. Hernándezes_ES
dc.relation.ispartofHistology and histopathologyes_ES
dc.subjectNeuromedin Nes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes_ES
dc.titleDifferent effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortexes_ES
Aparece en las colecciones:Vol. 9, nº 3 (1994)

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