Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/18509

Title: Neuromedins and their involvement in the regulation of growth, structure and function of the adrenal cortex
Issue Date: 1994
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Hypothalamus
Pituitary
Abstract: Current data on the synthesis and the mechanism of action of neuromedins on adrenal cortex are presented. The localization of these biologicallyactive peptides in all components of the hypothalamopituitary- adrenal axis as well as their action on the adrenal cortex both in vivo and in vitro suggest their involvement in the regulation of growth, structure and function of the adrenal cortex. Neuromedins may exert both direct and indirect effect on the adrenal cortex. Direct effect is proven by the stimulation of glucocorticoid synthesis by adrenocortical cells in culture (NMK, NML) while indirect effects may be mediated by ACTH, vasopressin (aldosterone secretagogue effect) and angiotensin (prompt proliferative response) or by substances of medullary origin. The last mechanism of action is well documented for NMU.
Primary author: Malendowicz, L.K.
Markowska, A.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/18509
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 11
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol. 9, nº 3 (1994)



Items in Digitum are protected by copyright, with all rights reserved, unless otherwise indicated.