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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Rontogianni, D. | es |
dc.contributor.author | Gerber, H. | es |
dc.contributor.author | Zimmermann, Astrid | - |
dc.date.accessioned | 2011-02-01T09:17:52Z | - |
dc.date.available | 2011-02-01T09:17:52Z | - |
dc.date.issued | 1994 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/18485 | - |
dc.description.abstract | We have studied the distribution patterns of antigen-presenting cells (APCs) in different stages of primary biliary cirrhosis (PBC). 58% of cases with early PBC (stages I and 11) exhibited dendritic APCs (S-loo+, HLA-DR+, KiMlp+) in bile duct epithelia. In contrast, APCs, were not detected in ductular proliferations occurring in late PBC (stages I11 and IV), but occurred in portal tracts and piecemeal necroses. There was a correlation between the presence of APCs and HLA-DR expression in bile ducts but, in contrast to former studies. we noted a heterogeneous ductal HLA expression. These observations support the hypothesis that: 1) APC distribution in PBC may change as a function of stage, involving hepatic parenchyma in late PBC; 2) ductular epithelia may not represent a target for immune attack, because APCs do not accumulate in these structures; and 3) HLA expression in bile ducts may be heterogeneous, suggesting one mechanism why bile duct destruction in PBC does not take place in a synchronous way. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Antigen presenting cells | es |
dc.subject | Primary biliary cirrhosis | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Primary biliary cirrhosis PBC, antigen-presenting cells differ in their distribution in early and late stage PBC and involve the ductal... | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol. 9, nº 2 (1994) |
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