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Título: | Transforming growth factor -a expression in rat experimental hepatocarcinogenesis |
Fecha de publicación: | 1992 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Hepatocarcinogenesis Tumour promotion |
Resumen: | Growth factors in general and transforming growth factor-a in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-a in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-a immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-a antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo. |
Autor/es principal/es: | Pérez-Tomás, R. Mayol, X. Culleré, X. Díaz Ruiz, C. Domingo, J. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18324 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 7, nº 3 (1992) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Transforming growth factor a expression in rat experimental hepatocarcinogenesis.pdf | 3,5 MB | Adobe PDF | Visualizar/Abrir |
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