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Título: | Regional variation in ontogeny of class II antigens in enterocytes of mouse small intestine |
Fecha de publicación: | 1992 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Enterocytes Small intestine |
Resumen: | The ontogeny of major histocompatibility class I1 antigens in small intestine enterocytes of postnatal C3HlHe mice was investigated. Cryosections of duodenal, jejunal, and ileal segments from 7-, 14-, 16-, 20-, 21-, 23-, 25-, 27-, 28-day-old and 7-week-old mice were stained for the class I1 antigens with MRC OX6 monoclonal antibodies by peroxidase-antiperoxidase labelling. In adults, the duodenum exhibited least expression of class I1 antigens that increased progressively towards the ileum. The expression in the villous epithelium was first seen in the duodenum and jejunum 21 days after birth but the ileal enterocytes did not exhibit any class I1 antigens. The earliest appearance (21 days postnatal) of class 11 antigens in the enterocytes coincides with the age of weaning which suggests that immunologic stimulation by ingested antigens after weaning may influence expression of these antigens. At day 28 after birth, the duodenum and jejunum expressed levels comparable to those in the adults. The first expression of the antigens seen in the ileum was at day 28 postpartum. Crypt epithelium of the three regions of the small intestine showed expression similar to that of corresponding regional villous enterocytes. We conclude that there is an age-dependent regional variation in the expression of class I1 antigens in enterocytes, and the expression increases with age. The variation in expression of the class I1 antigens in enterocytes of postnatal mice is attributed to the developmental status of the tissue. The nature of postnatal expression of the antigens is important since an early appearance of these antigens may have implications in autoimmunity. |
Autor/es principal/es: | Sidhu, Nirmal K. Wrightk, Glenda M. Markham, R.J. Fred Singh, Amreek |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18281 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 7, nº 1 (1992) |
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