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Title: Ultrastructural findings of congenital dyserythropoietic sickle cell beta thal-associated anemia
Issue Date: 1992
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina
Keywords: Erythroblasts
Abstract: The ultrastructural findings of erythroblasts and reticulocytes in one case of congenital dyserythropoiethic anemia (CDA) associated with a haemoglobinopathy, sickle cell beta thalassemia minor (Type V CDA), is described. The observations can be summarized as follows: 1) A lot of large breaks are present in the erythroblast nuclear envelope. 2) Nuclear membrane evaginations are filled with dense loose chromatin. 3) Electron-transparent areas (moth eaten chromatin) are evident in dense chromatin. 4) Electron-dense granular material, related to altered haemoglobin chain storage, is evident in the nucleus and in the cytoplasm. 5) Iron deposits are present in mitochondrial matrix. 6) Myelinic figures are present in reticulocyte cytoplasm. For the first time the ultrastructural findings in this type of associated CDA are described and related to the double origin of clinical symptoms.
Primary author: Dell`Orbo, Carlo
Marchi, Antonietta
Quacci, Daniela
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 4
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol. 7, nº 1 (1992)

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