lmmunohistological signposts in central nervous system tumours with neuronal differentiation

Abstract

25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retina1 S-antigen was detected only in one medulloblastoma, 314 pineal tumours and 212 retinoblastomas. Reactivity. for synaptophysin was present in 215 medulloblastomas, 3/10 neuroblastomas and 212 retinoblastomas. GFAP was demonstrated in scattered tumour cells in 415 medulloblastomas. Two of these were the only tumours featuring bipolar differentiation whilst it was unipolar in the remainder. The significance of these findings in relation to the ontogeny of these tumours is discussed.