Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/18239

Título: Leukocyte immunophenotypes in bronchoalveolar lavage fluid and peripheral blood of paracoccidioidomycosis, sarcoidosis and silicosis
Fecha de publicación: 1991
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Granulomatous diseases
Sarcoidosis
Resumen: Leukocyte subsets in bronchoalveolar lavage (BAL) fluid and peripheral blood of patients with paraccoccidioidomycosis, sarcoidosis and silicosis were characterized using monoclonal antibodies and an immunoperoxidase technique. In paraccocidioidomycosis, the number of T-helperl inducer CD4-positive lymphocytes was lower in peripheral blood than in BAL fluid. Additional analysis showed that the expression of HLA-DR was very similar in alveolar macrophages, lung and blood T-cells. In sarcoidosis and silicosis there were higher proportions of T-helperlinducer cells in peripheral blood than in BAL fluid. The alterations in the T-helperlinduceriT-suppressorl cytotoxic CD4lCD8 ratio in sarcoidosis and silicosis were more appreciable in peripheral blood than in BAL fluid, contrasting with the results in paracoccidioidomycosis. The expression of HLA-DR by alveolar macrophages in sarcoidosis was the highest of al1 the diseases studied. No statistically significant differences were observed between chronic multifocal and chronic unifocal paracoccidioidomycosis disease, stage 11 and stage 111 sarcoidosis, and chronic and accelerated silicosis. The three granulomatous diseases analyzed had a few alveolar macrophages expressing the CD4 molecule on their surface. These findings and the technique of analyzing both peripheral blood and BAL leukocyte subsets may help to understand the pathogenesis of interstitial lung diseases.
Autor/es principal/es: Tapia, F.J.
Goihman-Yahr, M.
Cáceres-Dittmar, G.
Altieri, E.
Gross, Ana
Isturiz, G.
Rosquete, R.
Viloria, N.
Ávila-Millán, E.
Carrasquero, M.
Borges, N.S.
Fernández, B.P.de
Rothenberg, A.
Albornoz, M.B.de
Pereira, J.
Gómez, M.H.de
San Martín, B.
Román, A.de
Bretaña, A.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18239
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 6, nº 3 (1991)

Ficheros en este ítem:
No hay ficheros asociados a este ítem.


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.