Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/18147

Título: Proliferation and distribution of adrenocortical cells in the gland of ACTH- or dexamethasone-treated rats
Fecha de publicación: 1990
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Adrenocortical cell turnover
Resumen: The effects of prolonged (7-day) ACTH and dexamethasone administrations on rat adrenocorticalcell turnover have been investigated by combined stereological and metaphase-arrest techniques. ACTH was found to increase the number of parenchymal cells in each adrenal zone; however, ACTH altered the cell distribution in the cortex, lowering their percentage in the zona glomerulosa (ZG) and zona fasciculata (ZF) and enhancing it in the zona reticularis (ZR). The cell birth-rate was markedly raised by ACTH exclusively in ZG and ZF. Dexamethasone notably decreased the number of ZF and ZR cells, without altering that of ZG cells. Moreover. dexamethasone increased the percentage of parenchymal cells in ZG and ZF, and lowered it in ZR. In the adrenal cortices of dexamethasoneadministered animals, metaphases were virtually absent. These data indicate that ACTH increases the cell birthrate in ZG and possibly ZF, and enhances the centripetal migration of newly-formed cells and their accumulation in ZR. Dexamethasone inhibits both proliferation of adrenocortical cells in the outer cortical layers and their centripetal migration into ZR. Moreover, it appears to cause parenchymal-cell loss in the inner adrenocortical layers.
Autor/es principal/es: Stachowiak, A.
Nussdorfer, G.G.
Malendowicz, L.K.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18147
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 5
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 5, nº 1 (1990)

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