Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/18134

Título: Prevention by aluminium phosphate of gastric lesions induced by ethanol in the rat, role of endogenous prostaglandins and sulfhydryls
Fecha de publicación: 1990
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Aluminium phosphate
Cytoprotection
Resumen: This study was designed to demonstrate the cytoprotective effect of an antacid containing aluminium phosphate (PhosphalugelB) against ethanol-induced gastric injury in the rat and to determine whether this cytoprotective effect is mediated by endogenous prostaglandins and sulfhydryls. We have quantitatively evaluated gastric mucosal lesions using macroscopic and histological techniques one hour after ethanol administration. Two m1 of aluminium phosphate given orally one hour before administration of 2 m1 of 100% ethanol significantly (p < 0.01) reduced the area of macroscopic lesions induced by ethanol (3.3 i 0.9%) when compared to distilled water (20 i 4.8%). The histological study showed that aluminium phosphate prevented deep tissue necrosis. However, it did not protect surface epithelial cells against ethanol injury. Pretreatment with indomethacin, 5 mglkg sc one hour before aluminium phosphate, slightly but significantly (p < 0.05) reduced the cytoprotective effect of aluminium phosphate. Macroscopic lesions occupied 4.3 i 0.94% and 1.88 i 0.41% of total mucosal area in indomethacin group and in vehicle group, respectively. On the other hand, the sulfhydryl blocker, N-ethylmaleimide, 10 mgíkg sc, given one hour before aluminium phosphate, completely abolished the cytoprotective effect of aluminium phosphate (32.92 i 4.85% in N-ethyl-maleimide group versus 3.78 i 1.41% in vehicle group; p < 0.01). These results show that aluminium phosphate has a cytoprotective effect against ethanol injury in the rat. This property appears to be mediated by both endogenous prostaglandins and sulfhydryls.
Autor/es principal/es: Duchateau, Alain
Thiefinl, Gérard
Varin-Bischoff, Sophie
Garbe, Edouard
Zeitoun, Paul
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/18134
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 5, nº 1 (1990)



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