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| Título: | Ultrastructural localization of Cu, Zn-SOD in hepatocytes of patients with various liver diseases |
| Fecha de publicación: | 1989 |
| Editorial: | Murcia : F. Hernández |
| ISSN: | 0213-3911 |
| Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
| Palabras clave: | Liver, Ultrastructure |
| Resumen: | The ultrastructural localization of copper, zinc-superoxide dismutase (Cu, Zn-SOD) in the liver of patients with acute hepatitis, chronic hepatitis, liver cirrhosis and alcoholic fatty liver was studied by means of the indirect immunoperoxidase technique. In hepatocytes Cu, Zn-SOD was found to be localized in perinuclear cisternae, rough endoplasmic reticulum (rER), vesicles and Golgi apparatus. The Cu, Zn-SOD was also detected around the lipid droplets in hepatocytes as well as on the cytoplasmic membrane in cases of liver cirrhosis. These findings suggest that Cu, Zn-SOD is produced in the rER in hepatocytes and protects the cells from cellular injury caused by superoxide anion radical in various disorders of the liver. |
| Autor/es principal/es: | Saito, Takafumi Shinzawa, Haruhide Togashi, Hitoshi Wakabayashi, Hiroto Ukai, Katsuaki Takahashi, Tsuneo Ishikawa, Makoto Dobashi, Michio Imai, Yutaka |
| URI: | http://hdl.handle.net/10201/17962 |
| Tipo de documento: | info:eu-repo/semantics/article |
| Número páginas / Extensión: | 6 |
| Derechos: | info:eu-repo/semantics/openAccess |
| Aparece en las colecciones: | Vol. 4, nº 1 (1989) |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Ultrastructural localization of Cu, Zn-SOD in hepatocytes of patients with various liver diseases.pdf | 667,55 kB | Adobe PDF |  Visualizar/Abrir |
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