Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/17825

Título: Observations on cell kinetics and viability of a human melanoma cell line exposed to dicarboxylic acids in tissue culture
Fecha de publicación: 1986
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.5 - Piel. Dermatología clínica
Palabras clave: Melanoma
Dicarboxylic acids
Resumen: Cultures of human nlelanonla cell line BOO08 \verc e-iposed to the disodium salts of arelaic acid (C,, 2Na), adipic acid (C,, 2Na) and dodecanediaic acid (C,, 2Na) at IO'M and 5 x 10-'M for 24 hrs. None of the diacid salts had a significant effect on growth rate or viability of the cells, at 10-'M for 24 hrs nor had C, 2Na any effect at 5 x 10'M. At 5 x 102M for 24 hrs, both C,, 2Na, and CIL2 Na had a significant effect in reducing both growth and viability. These effects were accompanied by morphological evidence of cell death, and swelling of mitochondria and accuni~~latioonf lipid droplets within cytoplasm of still biable cells.
Autor/es principal/es: Breathnach, A. S.
Robins, E.J.
Bhasin, Y. P.
Ethridge, L. B.
Nazzaro-Porro, M.
Passi, S.
Picardo, M.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/17825
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 5
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol. 1, nº 3 (1986)



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