Non Hodgkin's lymphomas following chemoradiotherapy for Hodgkin's disease. Two new cases and a review of the literature

Abstract

Two patients developed non-Hodgkin's lymphoma (NHL) six and ten years after radiotherapy and chemotherapy for Hodgkin's disease nodular sclerosis type. The histological classification of the developing NHL for the two patients was: IgG (K) secreting lymphoplasmacytoid lyn~phomao f the stomach, and immunoblastic lymphoma of [he cervical lymph nodes. Both patients responded well lo conventional chen~otherapyf or NHL and are alive 22 and 5 months after the diagnosis of the secondary tumor. Forty eight cases of NHL after treatment for HD have been previously reported. We present a review of the literature , of these cases, adding to this literature the first reported case of gastric lyniphoplasmacytoid lymphoma under such circumstances.