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| Título: | Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells |
| Fecha de publicación: | 26-oct-2022 |
| Editorial: | MDPI |
| Cita bibliográfica: | Molecules 2022, 27(21), 7264 |
| ISSN: | 1420-3049 |
| Palabras clave: | Ruthenium Complexes Cytotoxicity Anticancer activity HeLa MTT assay |
| Resumen: | When the [Ru(p-cymene)( -Cl)Cl]2 complex is made to react, in dichloromethane, with the following ligands: 2-aminobenzonitrile (2abn), 4-aminobenzonitrile (4abn), 2-aminopyridine (2ampy) and 4-aminopyridine (4ampy), after addition of hexane, the following compounds are obtained: [Ru(p-cymene)Cl2(2abn)] (I), [Ru(p-cymene)Cl2(4abn)] (II), [Ru(p-cymene)Cl2(2ampy] (III) and [Ru(pcymene) Cl2( -(4ampy)] (IV). All the compounds are characterized by elemental analysis of carbon, hydrogen and nitrogen, proton nuclear magnetic resonance, COSY 1H-1H, high-resolution mass spectrometry (ESI), thermogravimetry and single-crystal X-ray diffraction (the crystal structure of III is reported and compared with the closely related literature of II). The cytotoxicity effects of complexes were described for cervical cancer HeLa cells via 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay. The results demonstrate a low in vitro anticancer potential of the complexes. |
| Autor/es principal/es: | Fuster, M. G. Moulefera, I. Montalbán, M. G. Pérez, J. Víllora, G. García, G. |
| Facultad/Servicios: | Facultad de Química |
| Versión del editor: | https://www.mdpi.com/1420-3049/27/21/7264 |
| URI: | http://hdl.handle.net/10201/157481 |
| DOI: | https://doi.org/10.3390/molecules27217264 |
| Tipo de documento: | info:eu-repo/semantics/article |
| Número páginas / Extensión: | 11 |
| Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
| Descripción: | © 2022 by the authors____ This document is the published version of a published work that appeared in final form in Molecules____ This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 ____ To access the final edited and published work see: https://doi.org/10.3390/molecules27217264 |
| Aparece en las colecciones: | Artículos |
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