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https://doi.org/10.1186/s40425-019-0565-5
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| Título: | Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen |
| Fecha de publicación: | 8-abr-2019 |
| Editorial: | BMJ Publishing Group |
| Cita bibliográfica: | Journal for ImmunoTherapy of Cancer, 2019, Vol. 7 (1) : 100 |
| ISSN: | Electronic: 2051-1426 |
| Palabras clave: | Conventional dendritic cells cDC1 Cancer immunotherapy Vaccination Cell associated antigen Cross presenting dentritic cells Immunogenic cell death |
| Resumen: | The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exogenous antigen on MHC-I and can be fostered by immunogenic cancer cell death. Translational and clinical research has focused on in vitro-generated monocyte-derived DCs, while the vaccination efficacy of natural conventional type 1 DCs (cDC1s), which are associated with improved anti-tumor immunity and specialize on antigen cross-presentation, remains unknown. |
| Autor/es principal/es: | Wculek, Stefanie K. Amores Iniesta, Joaquín Conde Garrosa, Ruth Kouili, Sofía C. Melero, Ignacio Sancho, David |
| Versión del editor: | https://jitc.bmj.com/content/7/1/100.info |
| URI: | http://hdl.handle.net/10201/145401 |
| DOI: | https://doi.org/10.1186/s40425-019-0565-5 |
| Tipo de documento: | info:eu-repo/semantics/article |
| Número páginas / Extensión: | 16 |
| Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
| Descripción: | © The Author(s) 2019. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in Journal for ImmunoTherapy of Cancer. To access the final edited and published work see https://doi.org/10.1186/s40425-019-0565-5 |
| Aparece en las colecciones: | Informes o documentos de trabajo |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| 2019 Wculek et al., JITC Immunotherapy cDC1.pdf | 1,7 MB | Adobe PDF |  Visualizar/Abrir |
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