1. Digitum: Repositorio Institucional de la Universidad de Murcia
  2. Investigación
  3. Informes o documentos de trabajo
Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.1186/s40425-019-0565-5

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorWculek, Stefanie K.-
dc.contributor.authorAmores Iniesta, Joaquín-
dc.contributor.authorConde Garrosa, Ruth-
dc.contributor.authorKouili, Sofía C.-
dc.contributor.authorMelero, Ignacio-
dc.contributor.authorSancho, David-
dc.date.accessioned2024-10-18T06:45:01Z-
dc.date.available2024-10-18T06:45:01Z-
dc.date.issued2019-04-08-
dc.identifier.citationJournal for ImmunoTherapy of Cancer, 2019, Vol. 7 (1) : 100es
dc.identifier.issnElectronic: 2051-1426-
dc.identifier.urihttp://hdl.handle.net/10201/145401-
dc.description© The Author(s) 2019. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in Journal for ImmunoTherapy of Cancer. To access the final edited and published work see https://doi.org/10.1186/s40425-019-0565-5es
dc.description.abstractThe manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exogenous antigen on MHC-I and can be fostered by immunogenic cancer cell death. Translational and clinical research has focused on in vitro-generated monocyte-derived DCs, while the vaccination efficacy of natural conventional type 1 DCs (cDC1s), which are associated with improved anti-tumor immunity and specialize on antigen cross-presentation, remains unknown.es
dc.formatapplication/pdfes
dc.format.extent16es
dc.languageenges
dc.publisherBMJ Publishing Groupes
dc.relationWork in the DS laboratory is funded by the CNIC and grant SAF2016–79040-R from Ministerio de Ciencia, Innovación e Universidades (MCIU), Agencia Estatal de Investigación and Fondo Europeo de Desarrollo Regional (FEDER); B2017/BMD-3733 Immunothercan-CM from Comunidad de Madrid; RD16/0015/0018-REEM from FIS-Instituto de Salud Carlos III, MICINN and FEDER; Acteria Foundation; Constantes y Vitales prize (Atresmedia); La Marató de TV3 Foundation (201723); and the European Research Council (ERC-2016-Consolidator Grant 725091). Work at the IM laboratory is funded by grants from MCIU (SAF2014–52361-R and SAF2017–83267-C2–1-R) and by European Commission VII Framework and Horizon 2020 programs (AICR), Fundación de la Asociación Española Contra el Cáncer (AECC), and Fundación BBVA. SKW is supported by a European Molecular Biology Organization Long-term Fellowship (grant ALTF 438–2016) and a CNIC-International Postdoctoral Program Fellowship (grant 17230–2016). SCK is a recipient of a FPU fellowship (FPU16/03142) from the Spanish Ministry of Education, Culture and Sports. IM and DS labs are funded by the European Commission (635122-PROCROP H2020). The CNIC is supported by the MCIU and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectConventional dendritic cellses
dc.subjectcDC1es
dc.subjectCancer immunotherapyes
dc.subjectVaccinationes
dc.subjectCell associated antigenes
dc.subjectCross presenting dentritic cellses
dc.subjectImmunogenic cell deathes
dc.titleEffective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigenes
dc.typeinfo:eu-repo/semantics/articlees
dc.relation.publisherversionhttps://jitc.bmj.com/content/7/1/100.infoes
dc.identifier.doihttps://doi.org/10.1186/s40425-019-0565-5-
dc.contributor.departmentDepartamento de Sanidad Animal-
Aparece en las colecciones:Informes o documentos de trabajo

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
2019 Wculek et al., JITC Immunotherapy cDC1.pdf1,7 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro sencillo del ítem Mostrar el registro PREMIS del ítem  Estadísticas


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons