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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Álvarez Rodríguez, Manuel | - |
dc.contributor.author | Martínez, Cristina | - |
dc.contributor.author | Wright, Dominic | - |
dc.contributor.author | Barranco, Isabel | - |
dc.contributor.author | Roca, Jordi | - |
dc.contributor.author | Rodríguez Martínez, Heriberto | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal | es |
dc.date.accessioned | 2024-09-06T07:20:38Z | - |
dc.date.available | 2024-09-06T07:20:38Z | - |
dc.date.issued | 2020-02-25 | - |
dc.identifier.citation | Int. J. Mol. Sci. 2020, 21, 1572 | es |
dc.identifier.issn | Print: 1661-6596 | - |
dc.identifier.issn | Electronic: 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143679 | - |
dc.description | © 2020 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms21051572 | - |
dc.description.abstract | In the study presented here we identified transcriptomic markers for fertility in the cargo of pig ejaculated spermatozoa using porcine-specific micro-arrays (GeneChip® miRNA 4.0 and GeneChip® Porcine Gene 1.0 ST). We report (i) the relative abundance of the ssc-miR-1285, miR-16, miR-4332, miR-92a, miR-671-5p, miR-4334-5p, miR-425-5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. An overrepresentation analysis of the protein class (PANTHER) identified significant fold-increases for C-C chemokine binding (GO:0019957): CCR7, which activates B- and T-lymphocytes, 8-fold increase), XCR1 and CXCR4 (with ubiquitin as a natural ligand, 1.24-fold increase), cytokine receptor activity (GO:0005126): IL23R receptor of the IL23 protein, associated to JAK2 and STAT3, 3.4-fold increase), the TGF-receptor (PC00035) genes ACVR1C and ACVR2B (12-fold increase). Moreover, two micro-RNAs (miR-221 and mir-621) were down- and up-regulated, respectively, in high-fertility males. In conclusion, boars with different fertility performance possess a wide variety of differentially expressed RNA present in spermatozoa that would be attractive targets as non-invasive molecular markers for predicting fertility. | es |
dc.format | application/pdf | es |
dc.format.extent | 23 | es |
dc.language | eng | es |
dc.publisher | MDPI | - |
dc.relation | This research was funded by the Research Council FORMAS, Stockholm (Project 2017-00946 and Project 2019-00288), the Swedish Research Council (Vetenskapsrådet, VR; project 2015-05919), the MINECO and FEDER (AGL2015-69738-R) Madrid (Spain) and the Seneca Foundation (20780/PD/18) Murcia (Spain). | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Transcriptomics | es |
dc.subject | Microarrays | - |
dc.subject | Bioinformatics | - |
dc.subject | Spermatozoa | - |
dc.subject | Fertility | - |
dc.subject | Pig | - |
dc.title | The transcriptome of pig spermatozoa, and its role in fertility | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/21/5/1572 | es |
dc.identifier.doi | https://doi.org/10.3390/ijms21051572 | - |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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ijms-21-01572-v2.pdf | 2,43 MB | Adobe PDF | Visualizar/Abrir |
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