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10.1093/europace/euv354
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Título: | Von Willebrand factor is associated with atrial fibrillation development in ischaemic patients after cardiac surgery |
Fecha de publicación: | sep-2016 |
Cita bibliográfica: | EP Europace, Volume 18, Issue 9, September 2016, Pages 1328–1334 |
ISSN: | 1532-2092 |
Palabras clave: | Atrial fibrillation Coronary artery bypass grafts CABG Aortic valve replacement Endothelium Fibrosis |
Resumen: | Aims Atrial fibrillation (AF) is associated with an increased morbidity and mortality after cardiac surgery. Von Willebrand factor (vWF) has been proposed as a biomarker of endothelial damage/dysfunction. We hypothesized that vWF levels could be used as valuable biomarker for AF occurrence after cardiac surgery. Moreover, we explored the potential association between vWF and tissue remodelling as possible implication in post-surgical AF. Methods and results We prospectively recruited 100 consecutive patients who undergoing programmed cardiac surgery with cardiopulmonary bypass and with no previous history of AF. Plasma vWF levels were determined from citrated plasma samples. Right atrial appendage tissue was obtained during cardiac surgery, and vWF expression as well as interstitial fibrosis was analysed by immunostaining and Masson's trichrome, respectively. We found raised vWF plasma levels in ischaemic vs. valvular patients (200.2 ± 66.3 vs. 157.2 ± 84.3 IU/dL; P = 0.015). Fibrosis degree was associated with plasma vWF levels. Plasma vWF was an independent prognostic marker for AF development in ischaemic patients [odds ratio, OR 6.44 (95% confidence interval, CI 1.40–36.57), P = 0.035]. Conclusion Plasma vWF levels are associated with tissue fibrosis in patients undergoing cardiac surgery and with post-surgical AF development in ischaemic patients. These findings suggest an association among vWF levels, atrial remodelling, and AF development. It is supported by higher vWF expression in right atrial tissue in ischaemic patients, who developed post-surgical AF. |
Autor/es principal/es: | Hernández Romero, Diana Lahoz, Álvaro Roldan, Vanessa Jover, Eva Romero Aniorte, Ana I. Martínez, Carlos M. Jara Rubio, Rubén Arribas, José María García Alberola, Arcadio Cánovas López, Sergio Valdés, Mariano Marín, Francisco |
URI: | http://hdl.handle.net/10201/143262 |
DOI: | 10.1093/europace/euv354 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Artículos: Cirugía, Pediatría y Obstetricia y Ginecología |
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