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https://doi.org/10.1016/j.humimm.2011.06.004
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Blanco García, R. M. | - |
dc.contributor.author | López Álvarez, María R. | - |
dc.contributor.author | Garrido, I. P. | - |
dc.contributor.author | Salgado Cecilia, G. | - |
dc.contributor.author | Campillo, José Antonio | - |
dc.contributor.author | Bolarín, José Miguel | - |
dc.contributor.author | Legaz Pérez, Isabel | - |
dc.contributor.author | Muro, Manuel | - |
dc.contributor.author | García Alonso, A.M. | - |
dc.contributor.author | Martínez Sánchez, María V. | - |
dc.contributor.author | Peña Moral, J.M. de la | - |
dc.contributor.author | Pascual Figal, Domingo A. | - |
dc.contributor.author | Álvarez López, María Rocio | - |
dc.contributor.author | Miras, M. | - |
dc.contributor.author | Minguela, Alfredo | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | - |
dc.date.accessioned | 2024-07-12T08:09:48Z | - |
dc.date.available | 2024-07-12T08:09:48Z | - |
dc.date.issued | 2011-06-22 | - |
dc.identifier.citation | Human Immunology 72 (2011) 841-848 | es |
dc.identifier.issn | Print: 0198-8859 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143047 | - |
dc.description | © 2011 American Society for Histocompatibility and Immunogenetics. This document is the Published versión of a published Work that appeared in final form in Human Immunology. To access the final edited and published work see https://doi.org/10.1016/j.humimm.2011.06.004 | - |
dc.description.abstract | Viral infections and cellular acute rejection (AR) condition immunosuppressive therapy and compromise the evolution of allografts. Immune monitoring can be useful for ascertaining rejection and for differentiating allo-reaction from activation induced by infections. This work analyzes the usefulness of monitoring the expression of CD28 and KIR2D receptors in peripheral blood T lymphocytes by flow cytometry, to ascertain the immune response in heart and liver transplant recipients. In both types of transplant, the up-regulation of CD28 in CD4+ lymphocytes in the periods of greatest AR frequency indicates an effective allo-response, whereas the post-transplantation emergence of circulating CD8+CD28− and CD8+CD28−KIR2D+ T cells correlates with better early clinical results. Cytomegalovirus (CMV) infection, but not hepatitis C virus (HCV) or other infections, abrogated both CD28 up-regulation and CD8+CD28−KIR2D+ T-cell expansion. Our results show that monitoring the expression of CD28 and KIR2D receptors on T lymphocytes might be considered as sensors of the immune status of heart and liver recipients. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Elsevier | - |
dc.relation | This work was supported by SénecaFundation, CajaMurcia and Instituto de Salud Carlos III (ISCiii, 07/1224), Ministerio de Ciencia e Innovación, Spain. CIBERehd is funded by ISCiii, Centro de Investigación Biomédica en Red de Enfermedades HepÂticas y Digestivas, CIBEREHD. Blanco-García and López-Alvarez were funded by Fundación Séneca and CIBERehd | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | Heart transplantation | es |
dc.subject | Liver transplantation | es |
dc.subject | CD28 | es |
dc.subject | KIR2D | es |
dc.subject | CMV | es |
dc.title | CD28 and KIR2D receptors as sensors of the immune status in heart and liver transplantation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.1016/j.humimm.2011.06.004 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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1-s2.0-S0198885911001480-main.pdf | 2,44 MB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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