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https://doi.org/10.1007/s00251-013-0682-0
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Título: | KIR gene variability in cutaneous malignant melanoma: influence of KIR2D/HLA-C pairings on disease susceptibility and prognosis |
Fecha de publicación: | 31-ene-2013 |
Editorial: | Springer |
Cita bibliográfica: | Immunogenetics (2013) 65:333–343 |
ISSN: | Print: 0093-7711 Electronic: 1432-1211 |
Palabras clave: | Melanoma KIR receptors HLA class I ligands Sentinel lymph node metastasis Ulceration |
Resumen: | Natural killer and CD8+ T cells are believed to be involved in the immune protection against melanoma. Their function may be regulated by a group of receptors defined as killer immunoglobulin-like receptors (KIRs) and their cognate HLA class I ligands. In this study, we analyzed the influence of KIR genes and KIR/HLA-I combinations on melanoma susceptibility and/or prognosis in a Spanish Caucasian population. For this purpose, KIR genotyping by PCR-SSP and HLA-C genotyping by reverse PCR-SSO were performed in 187 melanoma patients and 200 matched controls. We found a significantly low frequency of KIR2DL3 in nodular melanoma (NM) patients (P = 0.001) and in ulcerated melanoma patients (P < 0.0001). Similarly, the KIR2DL3/C1 combination was significantly decreased in melanoma patients (P c = 0.008) and in patients with sentinel lymph node (SLN) melanoma metastasis (P c = 0.002). Multivariate logistic regression models showed that KIR2DL3 behaves as a protective marker for NM and ulcerated melanoma (P = 0.02, odds ratio (OR) = 0.14 and P = 0.04, OR = 0.28, respectively), whereas the KIR2DL3/C1 pair acts as a protective marker for melanoma (P = 0.017, OR = 0.54), particularly superficial spreading melanoma (P = 0.02, OR = 0.52), and SLN metastasis (P = 0.0004, OR = 0.14). In contrast, the KIR2DL3(−)/C1C2 genotype seems to be correlated with NM and ulceration. We also report that the KIR2DL1(+)/S1(−)/C2C2 genotype is associated with susceptibility to melanoma and SLN metastasis. Altogether, the study of KIR2D genes and HLA-C ligands may help in assessing cutaneous melanoma risk and prognosis. |
Autor/es principal/es: | Campillo, José A. Legaz Pérez, Isabel López Álvarez, M. Rocío Bolarín, José Miguel Heras, Beatriz de las Muro, Manuel Minguela, Alfredo Moya Quiles, María Rosa Blanco García, Rosa Martínez Banaclocha, Helios García Alonso, Ana M. Álvarez López, María Rocío Martínez Escribano, Jorge A. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias |
URI: | http://hdl.handle.net/10201/143046 |
DOI: | https://doi.org/10.1007/s00251-013-0682-0 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © Springer-Verlag Berlin Heidelberg 2013.This document is the Published version of a Published Work that appeared in final form in Immunogenetics. To access the final edited and published work see https://doi.org/10.1007/s00251-013-0682-0 |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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