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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Campillo, José A. | - |
dc.contributor.author | Legaz Pérez, Isabel | - |
dc.contributor.author | López Álvarez, M. Rocío | - |
dc.contributor.author | Bolarín, José Miguel | - |
dc.contributor.author | Heras, Beatriz de las | - |
dc.contributor.author | Muro, Manuel | - |
dc.contributor.author | Minguela, Alfredo | - |
dc.contributor.author | Moya Quiles, María Rosa | - |
dc.contributor.author | Blanco García, Rosa | - |
dc.contributor.author | Martínez Banaclocha, Helios | - |
dc.contributor.author | García Alonso, Ana M. | - |
dc.contributor.author | Álvarez López, María Rocío | - |
dc.contributor.author | Martínez Escribano, Jorge A. | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | - |
dc.date.accessioned | 2024-07-12T08:03:56Z | - |
dc.date.available | 2024-07-12T08:03:56Z | - |
dc.date.issued | 2013-01-31 | - |
dc.identifier.citation | Immunogenetics (2013) 65:333–343 | es |
dc.identifier.issn | Print: 0093-7711 | - |
dc.identifier.issn | Electronic: 1432-1211 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143046 | - |
dc.description | © Springer-Verlag Berlin Heidelberg 2013.This document is the Published version of a Published Work that appeared in final form in Immunogenetics. To access the final edited and published work see https://doi.org/10.1007/s00251-013-0682-0 | - |
dc.description.abstract | Natural killer and CD8+ T cells are believed to be involved in the immune protection against melanoma. Their function may be regulated by a group of receptors defined as killer immunoglobulin-like receptors (KIRs) and their cognate HLA class I ligands. In this study, we analyzed the influence of KIR genes and KIR/HLA-I combinations on melanoma susceptibility and/or prognosis in a Spanish Caucasian population. For this purpose, KIR genotyping by PCR-SSP and HLA-C genotyping by reverse PCR-SSO were performed in 187 melanoma patients and 200 matched controls. We found a significantly low frequency of KIR2DL3 in nodular melanoma (NM) patients (P = 0.001) and in ulcerated melanoma patients (P < 0.0001). Similarly, the KIR2DL3/C1 combination was significantly decreased in melanoma patients (P c = 0.008) and in patients with sentinel lymph node (SLN) melanoma metastasis (P c = 0.002). Multivariate logistic regression models showed that KIR2DL3 behaves as a protective marker for NM and ulcerated melanoma (P = 0.02, odds ratio (OR) = 0.14 and P = 0.04, OR = 0.28, respectively), whereas the KIR2DL3/C1 pair acts as a protective marker for melanoma (P = 0.017, OR = 0.54), particularly superficial spreading melanoma (P = 0.02, OR = 0.52), and SLN metastasis (P = 0.0004, OR = 0.14). In contrast, the KIR2DL3(−)/C1C2 genotype seems to be correlated with NM and ulceration. We also report that the KIR2DL1(+)/S1(−)/C2C2 genotype is associated with susceptibility to melanoma and SLN metastasis. Altogether, the study of KIR2D genes and HLA-C ligands may help in assessing cutaneous melanoma risk and prognosis. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Springer | - |
dc.relation | This work was supported by project PI-11/02644 from Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, by project 04487/GERM/06 from the Séneca Foundation, Consejería de Educación CCAA Murcia, and by the collaboration of Cajamurcia. Isabel Legaz and Mª Rocio López-Álvarez are postdoctoral researchers from the Spanish Health Ministry and Séneca Foundation, respectively. | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | Melanoma | es |
dc.subject | KIR receptors | es |
dc.subject | HLA class I ligands | es |
dc.subject | Sentinel lymph node metastasis | es |
dc.subject | Ulceration | es |
dc.title | KIR gene variability in cutaneous malignant melanoma: influence of KIR2D/HLA-C pairings on disease susceptibility and prognosis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.1007/s00251-013-0682-0 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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