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https://doi.org/10.1111/cei.13533
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Boix, F. | - |
dc.contributor.author | Legaz Pérez, Isabel | - |
dc.contributor.author | Alfaro, R. | - |
dc.contributor.author | Jiménez Coll, Victor | - |
dc.contributor.author | Mrowirc, A. | - |
dc.contributor.author | Martínez Banaclocha, Helios | - |
dc.contributor.author | Galián, José Antonio | - |
dc.contributor.author | Botella, Carmen | - |
dc.contributor.author | Moya Quiles, María Rosa | - |
dc.contributor.author | Sánchez Bueno, F. | - |
dc.contributor.author | Robles, R. | - |
dc.contributor.author | Peña Moral, J. de la | - |
dc.contributor.author | Ramírez, P. | - |
dc.contributor.author | Pons, J.A. | - |
dc.contributor.author | Minguela, Alfredo | - |
dc.contributor.author | Muro, Manuel | - |
dc.contributor.author | Minhas, A. | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | - |
dc.date.accessioned | 2024-07-12T10:56:03Z | - |
dc.date.available | 2024-07-12T10:56:03Z | - |
dc.date.issued | 2020-10-29 | - |
dc.identifier.citation | Clinical and Experimental Immunology, 203: 315–328 | es |
dc.identifier.issn | Print: 0009-9104 | - |
dc.identifier.issn | Electronic: 1365-2249 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143032 | - |
dc.description.abstract | Decreasing graft rejection and increasing graft and patient survival are great challenges facing liver transplantation (LT). Different T cell subsets participate in the acute cellular rejection (ACR) of the allograft. Cell-mediated immunity markers of the recipient could help to understand the mechanisms underlying acute rejection. This study aimed to analyse different surface antigens on T cells in a cohort of adult liver patients undergoing LT to determine the influence on ACR using multi-parametric flow cytometry functional assay. Thirty patients were monitored at baseline and during 1 year post-transplant. Two groups were established, with (ACR) and without (NACR) acute cellular rejection. Leukocyte, total lymphocyte, percentages of CD4+CD154+ and CD8+CD154+ T cells, human leukocyte antigen (HLA) mismatch between recipient–donor and their relation with ACR as well as the acute rejection frequencies were analysed. T cells were stimulated with concanavalin A (Con-A) and surface antigens were analysed by fluorescence activated cell sorter (FACS) analysis. A high percentage of CD4+CD154+ T cells (P = 0·001) and a low percentage of CD8+CD154+ T cells (P = 0·002) at baseline were statistically significant in ACR. A receiver operating characteristic analysis determined the cut-off values capable to stratify patients at high risk of ACR with high sensitivity and specificity for CD4+CD154+ (P = 0·001) and CD8+CD154+ T cells (P = 0·002). In logistic regression analysis, CD4+CD154+, CD8+CD154+ and HLA mismatch were confirmed as independent risk factors to ACR. Post-transplant percentages of both T cell subsets were significantly higher in ACR, despite variations compared to pretransplant. These findings support the selection of candidates for LT based on the pretransplant percentages of CD4+CD154+ and CD8+CD154+ T cells in parallel with other transplant factors. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 | es |
dc.language | eng | es |
dc.publisher | Oxford University Press | - |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | Acute cellular rejection | es |
dc.subject | CD154+ T cells | es |
dc.subject | Cell-mediated immunity (CMI) | es |
dc.subject | HLA | es |
dc.subject | Immunosuppression | es |
dc.subject | Liver transplantation | es |
dc.title | Identification of peripheral CD154+ T cells and HLA-DRB1 as biomarkers of acute cellular rejection in adult liver transplant recipients | es |
dc.type | info:eu-repo/semantics/article | es |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.1111/cei.13533 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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