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https://doi.org/10.1016/j.transproceed.2016.09.028
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Eguía, J. | - |
dc.contributor.author | González Martínez, G. | - |
dc.contributor.author | De La Peña, J. | - |
dc.contributor.author | Galian, J.A. | - |
dc.contributor.author | Hernández Martínez, A.M. | - |
dc.contributor.author | Moya Quiles, M.R. | - |
dc.contributor.author | Legaz Pérez, Isabel | - |
dc.contributor.author | Campillo, J.A. | - |
dc.contributor.author | Ramírez, P. | - |
dc.contributor.author | Sánchez Bueno, F. | - |
dc.contributor.author | García Alonso, A.M. | - |
dc.contributor.author | Pons, J.A. | - |
dc.contributor.author | Minguela, A. | - |
dc.contributor.author | Llorente, S. | - |
dc.contributor.author | Muro, M. | - |
dc.contributor.author | Bolarín, J.M. | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | - |
dc.date.accessioned | 2024-07-12T08:39:30Z | - |
dc.date.available | 2024-07-12T08:39:30Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | Transplantation Proceedings, 2016, Vol. 48, Issue 9, pp. 2987-2989 | es |
dc.identifier.issn | Print: 0041-1345 | - |
dc.identifier.issn | Electronic: 1873-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143026 | - |
dc.description | © 2016 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Transplantation Proceedings. To access the final edited and published work see https://doi.org/10.1016/j.transproceed.2016.09.028 | - |
dc.description.abstract | Background Acute rejection (AR) remains a significant cause of graft loss. Better approaches to predict AR are being investigated. Surface CD28 protein is essential for T-cell proliferation and survival as well as cytokine production. Patients and Methods Pretransplant CD4+CD28+ peripheral T cells were examined in 30 liver recipients (LRs) and 31 kidney recipients (KRs) by flow cytometry. Results Pretransplant CD4+CD28+ T cells in LRs were significantly lower in rejectors than nonrejectors (P = .002). Furthermore, the total number of CD28 molecules per cell in LRs (P = .02) as well as KRs (P = .047) was significantly lower in rejectors than nonrejectors. The healthy group did not display differences when compared with patients with end-stage liver disease or renal failure; however, stratification analysis displayed higher levels of CD4+CD28+ when compared with rejected LRs (P = .04) but not KRs. CD28 levels <41.94% were able to discriminate LRs at high risk of AR (P = .003). Similarly, a total number of CD28 molecules ≤8359 (P = .031) in LRs and ≤7669 (P = .046) in KRs correlated with high risk of AR. Conclusion The preliminary results presented herein exhibit a fast and noninvasive method that assists clinicians to prevent AR by monitoring CD4+CD28+ peripheral T cells. | es |
dc.format | application/pdf | es |
dc.format.extent | 3 | es |
dc.language | eng | es |
dc.publisher | Elsevier | - |
dc.relation | This work was possible thanks to support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness, Grant Number PI11/02686 and PI15/01370, and cofunding of the European Union with European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe.” | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.title | Pretransplant CD28 Biomarker (Levels of Expression and Quantification of Molecules per Cell) in Peripheral CD4+ T Cells Predicts Acute Rejection Episodes in Liver and Kidney Recipients | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0041134516306662?via%3Dihub#abs0010 | - |
dc.embargo.terms | SI | - |
dc.identifier.doi | https://doi.org/10.1016/j.transproceed.2016.09.028 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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1-s2.0-S0041134516306662-main.pdf | 243,11 kB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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