Por favor, use este identificador para citar o enlazar este ítem:
https://doi.org/10.1016/j.transproceed.2016.09.028
![](/digitum/image/email_logo.png)
![](/digitum/image/logo-facebook.png)
Título: | Pretransplant CD28 Biomarker (Levels of Expression and Quantification of Molecules per Cell) in Peripheral CD4+ T Cells Predicts Acute Rejection Episodes in Liver and Kidney Recipients |
Fecha de publicación: | nov-2016 |
Editorial: | Elsevier |
Cita bibliográfica: | Transplantation Proceedings, 2016, Vol. 48, Issue 9, pp. 2987-2989 |
ISSN: | Print: 0041-1345 Electronic: 1873-2623 |
Resumen: | Background Acute rejection (AR) remains a significant cause of graft loss. Better approaches to predict AR are being investigated. Surface CD28 protein is essential for T-cell proliferation and survival as well as cytokine production. Patients and Methods Pretransplant CD4+CD28+ peripheral T cells were examined in 30 liver recipients (LRs) and 31 kidney recipients (KRs) by flow cytometry. Results Pretransplant CD4+CD28+ T cells in LRs were significantly lower in rejectors than nonrejectors (P = .002). Furthermore, the total number of CD28 molecules per cell in LRs (P = .02) as well as KRs (P = .047) was significantly lower in rejectors than nonrejectors. The healthy group did not display differences when compared with patients with end-stage liver disease or renal failure; however, stratification analysis displayed higher levels of CD4+CD28+ when compared with rejected LRs (P = .04) but not KRs. CD28 levels <41.94% were able to discriminate LRs at high risk of AR (P = .003). Similarly, a total number of CD28 molecules ≤8359 (P = .031) in LRs and ≤7669 (P = .046) in KRs correlated with high risk of AR. Conclusion The preliminary results presented herein exhibit a fast and noninvasive method that assists clinicians to prevent AR by monitoring CD4+CD28+ peripheral T cells. |
Autor/es principal/es: | Eguía, J. González Martínez, G. De La Peña, J. Galian, J.A. Hernández Martínez, A.M. Moya Quiles, M.R. Legaz Pérez, Isabel Campillo, J.A. Ramírez, P. Sánchez Bueno, F. García Alonso, A.M. Pons, J.A. Minguela, A. Llorente, S. Muro, M. Bolarín, J.M. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias |
Versión del editor: | https://www.sciencedirect.com/science/article/pii/S0041134516306662?via%3Dihub#abs0010 |
URI: | http://hdl.handle.net/10201/143026 |
DOI: | https://doi.org/10.1016/j.transproceed.2016.09.028 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 3 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2016 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Transplantation Proceedings. To access the final edited and published work see https://doi.org/10.1016/j.transproceed.2016.09.028 |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
1-s2.0-S0041134516306662-main.pdf | 243,11 kB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.