Por favor, use este identificador para citar o enlazar este ítem:
https://doi.org/10.1016/j.humimm.2010.12.015
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | López Álvarez, M.R. | - |
dc.contributor.author | Campillo, J.A. | - |
dc.contributor.author | Legaz Pérez, Isabel | - |
dc.contributor.author | Blanco García, R.M. | - |
dc.contributor.author | Salgado Cecilia, G. | - |
dc.contributor.author | Bolarín, J.M. | - |
dc.contributor.author | Gimeno, L. | - |
dc.contributor.author | Gil, J. | - |
dc.contributor.author | García Alonso, A.M. | - |
dc.contributor.author | Muro, M. | - |
dc.contributor.author | Álvarez López, M.R. | - |
dc.contributor.author | Miras, M. | - |
dc.contributor.author | Minguela, A. | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | - |
dc.date.accessioned | 2024-07-12T08:21:12Z | - |
dc.date.available | 2024-07-12T08:21:12Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | Human Immunology, 2011, Vol. 72, Issue 3, pp. 229-237 | es |
dc.identifier.issn | Print: 0198-8859 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143025 | - |
dc.description | © 2011 American Society for Histocompatibility and Immunogenetics. This document is the Published version of a Published Work that appeared in final form in Human Immunology. To access the final edited and published work see https://doi.org/10.1016/j.humimm.2010.12.015 | - |
dc.description.abstract | Natural killer (NK) and CD8+ T cells may be active elements in the allograft response, but little is known about their role in liver transplantation. Some of these cells express killer immunoglobulin-like receptors (KIRs), which after binding specific ligands may transmit inhibitory/activating signals. In this study, circulating NK and CD8+ T cells expressing CD158a/h (KIR2DL1/S1) or CD158b/j (KIR2DL2/3/S2) receptors were analyzed in 142 liver recipients by flow cytometry. They were underrepresented in patients before transplantation, but following transplantation, whereas the KIR2D+ NK subsets experienced a late recuperation (day 365) mainly in C2-homozygous patients developing early acute rejection, recovery of the 2 CD8+KIR2D+ T cells started earlier, showing significant differences on day 365 between patients without acute rejection and those suffering from it (p = 0.004 and p < 0.0001, respectively). These differences were also evident when the human leukocute antigen-C genotypes of the recipient were considered. In conclusion, whereas the late recovery of KIR2D+ NK cells in C2/C2 patients appears to be linked to acute rejection, the increase in early CD8+KIR2D+ T cells in overall liver recipients correlates with a most successful early graft outcome. Therefore, monitoring of KIR2D+ cells appears to be a useful tool for liver transplant follow-up. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Elsevier | - |
dc.relation | This work was supported by the CIBERehd program and 07/1224 and 10/01964 projects from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain, and Caja Murcia (2008–2010) aid, and by Fundación Séneca, Murcia, Spain (Project 04087/GERM/06 ). The research work of María Rocío López-Álvarez was financed by the CIBERehd Program. | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | NK cells | es |
dc.subject | CD8 T lymphocytes | es |
dc.subject | KIR2D receptors | es |
dc.subject | Liver transplantation | es |
dc.subject | Tolerance | es |
dc.title | Divergences in KIR2D+ natural killer and KIR2D+CD8+ T-cell reconstitution following liver transplantation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0198885910005781#aep-acknowledgment-id21 | - |
dc.embargo.terms | SI | - |
dc.identifier.doi | https://doi.org/10.1016/j.humimm.2010.12.015 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
1-s2.0-S0198885910005781-main.pdf | 2,09 MB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.