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https://doi.org/10.1016/j.humimm.2010.12.015
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Título: | Divergences in KIR2D+ natural killer and KIR2D+CD8+ T-cell reconstitution following liver transplantation |
Fecha de publicación: | mar-2011 |
Editorial: | Elsevier |
Cita bibliográfica: | Human Immunology, 2011, Vol. 72, Issue 3, pp. 229-237 |
ISSN: | Print: 0198-8859 |
Palabras clave: | NK cells CD8 T lymphocytes KIR2D receptors Liver transplantation Tolerance |
Resumen: | Natural killer (NK) and CD8+ T cells may be active elements in the allograft response, but little is known about their role in liver transplantation. Some of these cells express killer immunoglobulin-like receptors (KIRs), which after binding specific ligands may transmit inhibitory/activating signals. In this study, circulating NK and CD8+ T cells expressing CD158a/h (KIR2DL1/S1) or CD158b/j (KIR2DL2/3/S2) receptors were analyzed in 142 liver recipients by flow cytometry. They were underrepresented in patients before transplantation, but following transplantation, whereas the KIR2D+ NK subsets experienced a late recuperation (day 365) mainly in C2-homozygous patients developing early acute rejection, recovery of the 2 CD8+KIR2D+ T cells started earlier, showing significant differences on day 365 between patients without acute rejection and those suffering from it (p = 0.004 and p < 0.0001, respectively). These differences were also evident when the human leukocute antigen-C genotypes of the recipient were considered. In conclusion, whereas the late recovery of KIR2D+ NK cells in C2/C2 patients appears to be linked to acute rejection, the increase in early CD8+KIR2D+ T cells in overall liver recipients correlates with a most successful early graft outcome. Therefore, monitoring of KIR2D+ cells appears to be a useful tool for liver transplant follow-up. |
Autor/es principal/es: | López Álvarez, M.R. Campillo, J.A. Legaz Pérez, Isabel Blanco García, R.M. Salgado Cecilia, G. Bolarín, J.M. Gimeno, L. Gil, J. García Alonso, A.M. Muro, M. Álvarez López, M.R. Miras, M. Minguela, A. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias |
Versión del editor: | https://www.sciencedirect.com/science/article/pii/S0198885910005781#aep-acknowledgment-id21 |
URI: | http://hdl.handle.net/10201/143025 |
DOI: | https://doi.org/10.1016/j.humimm.2010.12.015 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2011 American Society for Histocompatibility and Immunogenetics. This document is the Published version of a Published Work that appeared in final form in Human Immunology. To access the final edited and published work see https://doi.org/10.1016/j.humimm.2010.12.015 |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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