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https://doi.org/10.2174/0929867322666150812144104
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Título: | Quinoxalines Potential to Target Pathologies |
Fecha de publicación: | 2015 |
Editorial: | Bentham Science Publishers |
Cita bibliográfica: | Current Medicinal Chemistry 22(26), 2015:3075-3108 |
ISSN: | Print: 0929-8673 Electronic: 1875-533X |
Palabras clave: | Biomedical activity Intracellular signaling Molecular targets Receptors Quinoxaline derivatives Therapeutic applications |
Resumen: | The study of quinoxalines has increased immeasurably during the last two decades, due firstly to their relatively simple chemical synthesis, which has generated a vast variety of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required for the development of new and more specific drugs through a rational design strategy to avoid undesirable side effects. In the present review, we summarize the most important molecular targets of the quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline- based therapies. |
Autor/es principal/es: | Martínez-Esparza, M. Tristán-Manzano, María Guirado, Antonio Gálvez, Jesús García-Peñarrubia, Pilar Ruiz-Alcaraz, Antonio José |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular B e Inmunología |
Versión del editor: | https://www.eurekaselect.com/article/69480 |
URI: | http://hdl.handle.net/10201/142796 |
DOI: | https://doi.org/10.2174/0929867322666150812144104 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 34 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2015 Bentham Science Publishers. This document is the Published version of a Published Work that appeared in final form in Current Medicinal Chemistry. To access the final edited and published work see https://doi.org/10.2174/0929867322666150812144104 |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
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Fichero | Descripción | Tamaño | Formato | |
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Quinoxalinas2015.pdf | 1,21 MB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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