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https://doi.org/10.2174/0929867322666150812144104
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Martínez-Esparza, M. | - |
dc.contributor.author | Tristán-Manzano, María | - |
dc.contributor.author | Guirado, Antonio | - |
dc.contributor.author | Gálvez, Jesús | - |
dc.contributor.author | García-Peñarrubia, Pilar | - |
dc.contributor.author | Ruiz-Alcaraz, Antonio José | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular B e Inmunología | es |
dc.date.accessioned | 2024-07-02T08:16:08Z | - |
dc.date.available | 2024-07-02T08:16:08Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Current Medicinal Chemistry 22(26), 2015:3075-3108 | es |
dc.identifier.issn | Print: 0929-8673 | - |
dc.identifier.issn | Electronic: 1875-533X | - |
dc.identifier.uri | http://hdl.handle.net/10201/142796 | - |
dc.description | © 2015 Bentham Science Publishers. This document is the Published version of a Published Work that appeared in final form in Current Medicinal Chemistry. To access the final edited and published work see https://doi.org/10.2174/0929867322666150812144104 | - |
dc.description.abstract | The study of quinoxalines has increased immeasurably during the last two decades, due firstly to their relatively simple chemical synthesis, which has generated a vast variety of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required for the development of new and more specific drugs through a rational design strategy to avoid undesirable side effects. In the present review, we summarize the most important molecular targets of the quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline- based therapies. | es |
dc.format | application/pdf | es |
dc.format.extent | 34 | es |
dc.language | eng | es |
dc.publisher | Bentham Science Publishers | es |
dc.relation | We gratefully acknowledge the financial support of the Fundación Séneca of the Comunidad Autónoma de la Región de Murcia (projects 11926/PI/09 and 08755/PI/08). | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | Biomedical activity | es |
dc.subject | Intracellular signaling | es |
dc.subject | Molecular targets | es |
dc.subject | Receptors | es |
dc.subject | Quinoxaline derivatives | es |
dc.subject | Therapeutic applications | es |
dc.title | Quinoxalines Potential to Target Pathologies | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.eurekaselect.com/article/69480 | es |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.2174/0929867322666150812144104 | - |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
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Fichero | Descripción | Tamaño | Formato | |
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Quinoxalinas2015.pdf | 1,21 MB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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