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https://doi.org/10.1016/j.carbpol.2019.115763
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| Título: | Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer study |
| Fecha de publicación: | 17-dic-2019 |
| Editorial: | Elsevier |
| Cita bibliográfica: | Carbohydrate Polymers 231 (2020) 115763 |
| ISSN: | Print: 0144-8617 Electronic: 1879-1344 |
| Palabras clave: | Stilbene Cyclodextrins Anticancer Nanosponges Methodology |
| Resumen: | The complexation of the bioactive compound oxyresveratrol (OXY) with a polymer called cyclodextrin-based nanosponge (CD-NS) and its application was studied.A new methodology is used to calculate, an apparent inclusion complex constant (KFapp) between a ligand and CD-NSs. Moreover, the KFapp of resveratrol was also evaluated and compared. The complex of OXY with the nanosponge β-CDI 1:4, was studied in vitro using DSC, TGA and FTIR techniques and its drug loading and release behavior were studied. An in vitro digestion showed higher protection of OXY complexed than free OXY. The bioactivity enhancing capacity of OXY was also studied against prostate (PC-3) and colon (HT-29 and HCT-116) cancer cell lines, where it showed stronger cell viability inhibition than the free drug. The findings as a whole represent a new opportunity for studying the complexation of drugs in CD-NSs and the use of oxyresveratrol as an ingredient in nutraceutical products. |
| Autor/es principal/es: | Matencio, Adrián Kumar Dhakarb, Nilesh Bessonec, Federica Musso, Giorgia Cavallic, Roberta Dianzanic, Chiara García Carmona, Francisco López Nicolás, José Manuel |
| Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular "A" |
| URI: | http://hdl.handle.net/10201/139200 |
| DOI: | https://doi.org/10.1016/j.carbpol.2019.115763 |
| Tipo de documento: | info:eu-repo/semantics/article |
| Número páginas / Extensión: | 7 |
| Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| Descripción: | ©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Carbohydrate Polymers. To access the final edited and published work see https://doi.org/10.1016/j.carbpol.2019.115763 |
| Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "A" |
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