Por favor, use este identificador para citar o enlazar este ítem:
http://dx.doi.org/10.5281/zenodo.1240558
Twittear
Título: | Identification of distinct pathological signatures induced by patient-derived -synuclein structures in nonhuman primates |
Fecha de publicación: | 13-may-2020 |
Editorial: | Asociación Estadounidense para el Avance de la Ciencia |
Cita bibliográfica: | Science Advances n. 6; año 2020 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Neuroscience Pathological signatures Synuclein structures in nonhuman primates |
Resumen: | Dopaminergic neuronal cell death, associated with intracellular -synuclein (-syn)–rich protein aggregates [termed “Lewy bodies” (LBs)], is a well-established characteristic of Parkinson’s disease (PD). Much evidence, accumulated from multiple experimental models, has suggested that -syn plays a role in PD pathogenesis, not only as a trigger of pathology but also as a mediator of disease progression through pathological spreading. Here, we have used a machine learning–based approach to identify unique signatures of neurodegeneration in monkeys induced by distinct -syn pathogenic structures derived from patients with PD. Unexpectedly, our results show that, in nonhuman primates, a small amount of singular -syn aggregates is as toxic as larger amyloid fibrils present in the LBs, thus reinforcing the need for preclinical research in this species. Furthermore, our results provide evidence supporting the true multifactorial nature of PD, as multiple causes can induce a similar outcome regarding dopaminergic neurodegeneration. |
Autor/es principal/es: | Herrero Ezquerro, María Trinidad Bourdenx, M. Nioche, A. Dovero, S. Arotcarena, M. L. Camus, S. Porras, G. Thiolat, M.L. Rougier, N. P. Prigent, A. Aubert, P. Bohic, S. Sandt, C. Leste-Lasserre, T. Trigo Damas, I. Goillandeau, M. Perier, C. Estrada, C. Garcia-Carrillo, N. Recasens, A. Vaikath, N. N. El-Agnaf, O. M. A. Derkinderen, P. Vila, M. Obeso, J.A. Dehay, B. Bezard, E. |
URI: | http://hdl.handle.net/10201/139133 |
DOI: | http://dx.doi.org/10.5281/zenodo.1240558 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 18 |
Derechos: | info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional |
Descripción: | ©<2020>. This manuscript version is made available under the CC BY-NC 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Submitted, Accepted, Published, version of a Published Work that appeared in final form in Science Advances To access the final edited and published work see http://dx.doi.org/10.5281/zenodo.1240558 |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Baboons 2020 26 Sciences Advances.pdf | 8,71 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons