Por favor, use este identificador para citar o enlazar este ítem:
http://dx.doi.org/10.5281/zenodo.1240558
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Herrero Ezquerro, María Trinidad | - |
dc.contributor.author | Bourdenx, M. | - |
dc.contributor.author | Nioche, A. | - |
dc.contributor.author | Dovero, S. | - |
dc.contributor.author | Arotcarena, M. L. | - |
dc.contributor.author | Camus, S. | - |
dc.contributor.author | Porras, G. | - |
dc.contributor.author | Thiolat, M.L. | - |
dc.contributor.author | Rougier, N. P. | - |
dc.contributor.author | Prigent, A. | - |
dc.contributor.author | Aubert, P. | - |
dc.contributor.author | Bohic, S. | - |
dc.contributor.author | Sandt, C. | - |
dc.contributor.author | Leste-Lasserre, T. | - |
dc.contributor.author | Trigo Damas, I. | - |
dc.contributor.author | Goillandeau, M. | - |
dc.contributor.author | Perier, C. | - |
dc.contributor.author | Estrada, C. | - |
dc.contributor.author | Garcia-Carrillo, N. | - |
dc.contributor.author | Recasens, A. | - |
dc.contributor.author | Vaikath, N. N. | - |
dc.contributor.author | El-Agnaf, O. M. A. | - |
dc.contributor.author | Derkinderen, P. | - |
dc.contributor.author | Vila, M. | - |
dc.contributor.author | Obeso, J.A. | - |
dc.contributor.author | Dehay, B. | - |
dc.contributor.author | Bezard, E. | - |
dc.date.accessioned | 2024-02-09T13:11:04Z | - |
dc.date.available | 2024-02-09T13:11:04Z | - |
dc.date.issued | 2020-05-13 | - |
dc.identifier.citation | Science Advances n. 6; año 2020 | es |
dc.identifier.uri | http://hdl.handle.net/10201/139133 | - |
dc.description | ©<2020>. This manuscript version is made available under the CC BY-NC 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Submitted, Accepted, Published, version of a Published Work that appeared in final form in Science Advances To access the final edited and published work see http://dx.doi.org/10.5281/zenodo.1240558 | es |
dc.description.abstract | Dopaminergic neuronal cell death, associated with intracellular -synuclein (-syn)–rich protein aggregates [termed “Lewy bodies” (LBs)], is a well-established characteristic of Parkinson’s disease (PD). Much evidence, accumulated from multiple experimental models, has suggested that -syn plays a role in PD pathogenesis, not only as a trigger of pathology but also as a mediator of disease progression through pathological spreading. Here, we have used a machine learning–based approach to identify unique signatures of neurodegeneration in monkeys induced by distinct -syn pathogenic structures derived from patients with PD. Unexpectedly, our results show that, in nonhuman primates, a small amount of singular -syn aggregates is as toxic as larger amyloid fibrils present in the LBs, thus reinforcing the need for preclinical research in this species. Furthermore, our results provide evidence supporting the true multifactorial nature of PD, as multiple causes can induce a similar outcome regarding dopaminergic neurodegeneration. | es |
dc.format | application/pdf | es |
dc.format.extent | 18 | es |
dc.language | eng | es |
dc.publisher | Asociación Estadounidense para el Avance de la Ciencia | es |
dc.relation | This work was supported by a grant from the Michael J. Fox Foundation (project grant number 2013-8499), Fundacion de Investigacion HM Hospitales (Madrid, Spain), the Fundación Séneca (project grant number FS19540/PI/14), the TARGET PD ANR grant, and The Simone and Cino Del Duca Prize from the French Academy of Sciences. J.-A.O. and I.T.D. were funded by MINECO/AEI/FEDER-UE (SAF2015-67239-P). M.B. and M.-L.A. were supported by a Ministère de l’Enseignement Supérieur et de la Recherche fellowship and the France Parkinson Foundation (M.B.). The help of the Bordeaux Imaging Center, part of the national infrastructure France BioImaging, granted by ANR-10INBS-04-0, is acknowledged. The human -Syn aggregation TR-FRET immunoassay was performed in the Biochemistry and Biophysics Platform of the Bordeaux Neurocampus at the Bordeaux University funded by the LABEX BRAIN (ANR-10-LABX-43) with the help of Y. Rufin. Computing time for this study was provided by the MCIA, the public research HPC center in Aquitaine, France. The samples were obtained from the Brain Bank GIE NeuroCEB (BRIF number 0033-00011), funded by the patients’ associations France Alzheimer, France Parkinson, ARSEP, and “Connaître les Syndromes Cérébelleux” to which we express our gratitude. The synchrotron Diamond is acknowledged for provision of beam time (exp. SP13009). | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Neuroscience | es |
dc.subject | Pathological signatures | es |
dc.subject | Synuclein structures in nonhuman primates | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Identification of distinct pathological signatures induced by patient-derived -synuclein structures in nonhuman primates | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | http://dx.doi.org/10.5281/zenodo.1240558 | - |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Baboons 2020 26 Sciences Advances.pdf | 8,71 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons