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https://doi.org/10.1186/s12917-018-1546-5
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Título: | Measurement of urea and creatinine in saliva of dogs: a pilot study |
Fecha de publicación: | 20-jul-2018 |
Editorial: | BMC |
Cita bibliográfica: | BMC Veterinary Research 14, (2018): 223 |
ISSN: | Electronic: 1746-6148 |
Resumen: | Background: Urea and creatinine in saliva have been reported to be possible markers of chronic kidney disease (CKD) in humans. The aim of this study was to assess if urea and creatinine could be measured in canine saliva, and to evaluate their possible changes in situations of CKD. Results: The spectrophotometric assays for urea and creatinine measurements in saliva of dogs showed intra- and inter-assay imprecision lower than 12% and coefficients of correlation close to 1 in linearity under dilution tests. Healthy dogs showed median salivary concentrations of urea of 39.6 mg/dL and creatinine of 0.30 mg/dL, whereas dogs with CKD showed median salivary urea of 270.1 mg/dL and creatinine of 1.86 mg/dL. Positive high correlations were found between saliva and serum activities of the two analytes (urea, r = 0.909; P < 0.001; creatinine, r = 0.819; P < 0.001). Conclusions: Urea and creatinine concentrations can be measured in canine saliva with commercially available spectrophotometric assays. Both analytes showed higher values in saliva of dogs with CKD compared with healthy dogs and their values were highly correlated with those in serum in our study conditions. |
Autor/es principal/es: | Tvarijonaviciute, Asta Pardo Marín, Luis Tecles, Fernando Carrillo, Juana Dolores García Martínez, Juan Diego Bernal, Luis J. Pastor, Josep Cerón, Jose J. Martínez Subiela, Silvia |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal |
Versión del editor: | https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1546-5 |
URI: | http://hdl.handle.net/10201/138959 |
DOI: | https://doi.org/10.1186/s12917-018-1546-5 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2018. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in BMC Veterinary Research. To access the final edited and published work see https://doi.org/10.1186/s12917-018-1546-5 |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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