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https://doi.org/10.1111/odi.13674
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Título: | Regeneration of lingual musculature in rats using myoblasts over porcine bladder acellular matrix |
Fecha de publicación: | 2021 |
Editorial: | Wiley |
Cita bibliográfica: | Oral Diseases 2021; 27(6):1580-1589 |
ISSN: | 1354-523X |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales |
Palabras clave: | Hemiglossectomized tongues Neonatal myoblasts Porcine acellular urinary bladder matrix Tissue engineering muscle repair Volumetric muscle loss |
Resumen: | Objectives: To use tissue engineering muscle repair (TEMR) for regenerating the lingual musculature of hemiglossectomized rats using neonatal myoblasts (NM) on porcine acellular urinary bladder matrix (AUBM). Material and Methods: The study used 80 male rats. A volumetric muscle loss (VML) injury was created on the left side of the tongue. The rats were randomized into four groups: Group 1 (AUBM + myoblasts); Group 2 (AUBM); Group 3 (myoblasts); and Group 4 (control). NM were obtained from neonatal rats. The animals were weighed on day 0 and just before euthanasia. Five rats in each group were euthanized at days 2, 14, 28, and 42; the tongues were prepared for morphometric analysis, postoperative left hemitongue weight, and immunohistochemical analysis (desmin, CD-31, and anti-neurofilament). Results: The weight gain from greatest to least was as follows: AUBM + myoblasts > myoblasts > AUBM > control. The tongue dorsum occupied by VML, and difference in mg between control side and intervened side from least to great was as follows: AUBM + myoblasts < myoblasts < AUBM < control. The order from highest to lowest antibody positivity was as follows: AUBM + myoblasts > myoblasts > AUBM > control. Conclusion: The use of porcine AUBM and NM for the regeneration of lingual musculature was found to be an effective TEMR treatment for repairing tongue VML injury. |
Autor/es principal/es: | Camacho Alonso, Fabio García Carrillo, Nuria Buendía, Antonio Julian Navarro, José Antonio Peñarrocha Oltra, David Peñarrocha Diago, Miguel Lacal Luján, José |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Dermatología, Estomatología, Radiología y Medicina Física |
URI: | http://hdl.handle.net/10201/138324 |
DOI: | https://doi.org/10.1111/odi.13674 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Aparece en las colecciones: | Artículos: Dermatología, Estomatología, Radiología y Medicina Física |
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Fichero | Descripción | Tamaño | Formato | |
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Oral Diseases - 2020 - Camacho‐Alonso - Regeneration of lingual musculature in rats using myoblasts over porcine bladder.2021 (27).pdf | 1,52 MB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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