Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.3389/fped.2019.00499

Título: Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma
Fecha de publicación: 2019
Cita bibliográfica: Frontiers in Pediatric, Sec. Pediatric Pulmonology Volume 7 - 2019
Resumen: Asthma is a heterogeneous disease that results from the complex interaction between genetic factors and environmental exposures that occur at critical periods throughout life. It seems plausible to regard childhood-onset and adult-onset asthma as different entities, each with a different pathophysiology, trajectory, and outcome. This review provides an overview about the role of genetics and gene-environment interactions in these two conditions. Looking at the genetic overlap between childhood and adult onset disease gives one window into whether there is a correlation, as well as to mechanism. A second window is offered by the genetics of the relationship between each type of asthma and other phenotypes e.g., obesity, chronic obstructive pulmonary disease (COPD), atopy, vitamin D levels, and inflammatory and immune status; and third, the genetic-specific responses to the many environmental exposures that influence risk throughout life, and particularly those that occur during early-life development. These represent a large number of possible combinations of genetic and environmental factors, at least 150 known genetic loci vs. tobacco smoke, outdoor air pollutants, indoor exposures, farming environment, and microbial exposures. Considering time of asthma onset extends the two-dimensional problem of gene-environment interactions to a three-dimensional problem, since identified gene-environment interactions seldom replicate for childhood and adult asthma, which suggests that asthma susceptibility to environmental exposures may biologically differ from early life to adulthood as a result of different pathways and mechanisms of the disease.
Autor/es principal/es: Morales, Eva
Duffy, David
Facultad/Departamentos/Servicios: Ciencias Sociosanitarias
URI: http://hdl.handle.net/10201/138226
DOI: https://doi.org/10.3389/fped.2019.00499
Tipo de documento: info:eu-repo/semantics/article
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Descripción: ©<2019>. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Frontiers in pediatrics. To access the final edited and published work see https://doi.org/10.3389/fped.2019.00499
Aparece en las colecciones:Artículos: Ciencias Sociosanitarias

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
59- Morales & Duffy-Front Pediatr 2019.pdf802,75 kBAdobe PDFVista previa

Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons