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10.3389/fnut.2022.869357
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Morales, Eva | - |
dc.contributor.author | García-Serna, Azahara M. | - |
dc.contributor.author | Larqué, Elvira | - |
dc.contributor.author | Sánchez-Campillo, María | - |
dc.contributor.author | Serrano-Munera, Ana | - |
dc.contributor.author | Martinez-Graciá, Carmen | - |
dc.contributor.author | Santaella-Pascual, Marina | - |
dc.contributor.author | Suárez-Martínez, Clara | - |
dc.contributor.author | Vioque, Jesús | - |
dc.contributor.author | Noguera-Velasco, José A. | - |
dc.contributor.author | Avilés-Plaza, Francisco V. | - |
dc.contributor.author | Martínez-Villanueva, Miriam | - |
dc.contributor.author | Ballesteros-Meseguer, Carmen | - |
dc.contributor.author | Galdo-Castiñeira, Lina | - |
dc.contributor.author | García-Marcos, Luis | - |
dc.contributor.other | Ciencias Sociosanitarias | es |
dc.date.accessioned | 2024-01-31T08:22:26Z | - |
dc.date.available | 2024-01-31T08:22:26Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Frontiers in Nutrition, Sec. Nutritional Epidemiology Volume 9 - 2022 | - |
dc.identifier.uri | http://hdl.handle.net/10201/138224 | - |
dc.description | ©<2022>. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Frontiers in nutrition. To access the final edited and published work see https://doi.org/10.3389/fnut.2022.869357 | - |
dc.description.abstract | Background: Although adherence to the Mediterranean and antioxidant-rich diets during pregnancy is suggested to improve maternal-fetal health by reducing oxidative stress, yet there is no study available. Objective: We examined whether maternal dietary patterns in pregnancy impact the biomarkers of oxidative stress in mothers and their offspring. Methods: Study population included 642 mothers and 335 newborns of the "Nutrition in Early Life and Asthma" (NELA) birth cohort. Maternal diet during pregnancy was assessed by a validated food frequency questionnaire and a priori-defined dietary indices (relative Mediterranean Diet [rMED], alternative Mediterranean Diet [aMED], Dietary Approach to Stop Hypertension [DASH], Alternate Healthy Index [AHEI], and AHEI-2010) were calculated. Biomarkers measured were: hydroperoxides, carbonyl groups, and 8-hydroxydeoxyguanosine (8OHdG) determined in maternal blood and newborn cord blood, and urinary maternal and offspring 15-F2t-isoprostane. Multivariate linear regression models were performed. Results: Maternal rMED score was inversely associated with the maternal levels of 8OHdG at mid-pregnancy (beta per 1-point increase = -1.61; 95% CI -2.82, -0.39) and the newborn levels of hydroperoxides (beta per 1-point increase = -4.54; 95% CI -9.32, 0.25). High vs. low maternal rMED score was marginally associated with the decreased levels of 8OHdG in newborns (beta = -9.17; 95% CI -19.9, 1.63; p for trend 0.079). Maternal DASH score tended to be inversely associated with maternal urinary 15-F2t-isoprostane (beta per 1-point increase = -0.69; 95% CI, -1.44, 0.06). High vs. low maternal AHEI score was associated with reduced offspring urinary levels of 15-F2t-isoprostane (beta = -20.2; 95% CI -38.0, -2.46; p for trend 0.026). Conclusion: These results suggest that maternal adherence to healthy dietary patterns during pregnancy may reduce DNA damage and lipid oxidation in mothers and offspring. | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.relation | Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and co-funded by the European Union (Grant Numbers: CP14/00046, PIE15/00051, PI16/00422, PI19/00863, and ARADyAL network RD160006). AG-S was funded by a predoctoral Fellowship (FI17/00086) and EM was funded by Miguel Servet Fellowships (MS14/00046 and CPII19/00019) awarded by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Dietary Patterns in Pregnancy and Biomarkers of Oxidative Stress in Mothers and Offspring: The NELA Birth Cohort | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.3389/fnut.2022.869357 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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