Por favor, use este identificador para citar o enlazar este ítem: 10.3389/fnut.2022.869357

Título: Dietary Patterns in Pregnancy and Biomarkers of Oxidative Stress in Mothers and Offspring: The NELA Birth Cohort
Fecha de publicación: abr-2022
Cita bibliográfica: Frontiers in Nutrition, Sec. Nutritional Epidemiology Volume 9 - 2022
Resumen: Background: Although adherence to the Mediterranean and antioxidant-rich diets during pregnancy is suggested to improve maternal-fetal health by reducing oxidative stress, yet there is no study available. Objective: We examined whether maternal dietary patterns in pregnancy impact the biomarkers of oxidative stress in mothers and their offspring. Methods: Study population included 642 mothers and 335 newborns of the "Nutrition in Early Life and Asthma" (NELA) birth cohort. Maternal diet during pregnancy was assessed by a validated food frequency questionnaire and a priori-defined dietary indices (relative Mediterranean Diet [rMED], alternative Mediterranean Diet [aMED], Dietary Approach to Stop Hypertension [DASH], Alternate Healthy Index [AHEI], and AHEI-2010) were calculated. Biomarkers measured were: hydroperoxides, carbonyl groups, and 8-hydroxydeoxyguanosine (8OHdG) determined in maternal blood and newborn cord blood, and urinary maternal and offspring 15-F2t-isoprostane. Multivariate linear regression models were performed. Results: Maternal rMED score was inversely associated with the maternal levels of 8OHdG at mid-pregnancy (beta per 1-point increase = -1.61; 95% CI -2.82, -0.39) and the newborn levels of hydroperoxides (beta per 1-point increase = -4.54; 95% CI -9.32, 0.25). High vs. low maternal rMED score was marginally associated with the decreased levels of 8OHdG in newborns (beta = -9.17; 95% CI -19.9, 1.63; p for trend 0.079). Maternal DASH score tended to be inversely associated with maternal urinary 15-F2t-isoprostane (beta per 1-point increase = -0.69; 95% CI, -1.44, 0.06). High vs. low maternal AHEI score was associated with reduced offspring urinary levels of 15-F2t-isoprostane (beta = -20.2; 95% CI -38.0, -2.46; p for trend 0.026). Conclusion: These results suggest that maternal adherence to healthy dietary patterns during pregnancy may reduce DNA damage and lipid oxidation in mothers and offspring.
Autor/es principal/es: Morales, Eva
García-Serna, Azahara M.
Larqué, Elvira
Sánchez-Campillo, María
Serrano-Munera, Ana
Martinez-Graciá, Carmen
Santaella-Pascual, Marina
Suárez-Martínez, Clara
Vioque, Jesús
Noguera-Velasco, José A.
Avilés-Plaza, Francisco V.
Martínez-Villanueva, Miriam
Ballesteros-Meseguer, Carmen
Galdo-Castiñeira, Lina
García-Marcos, Luis
Facultad/Departamentos/Servicios: Ciencias Sociosanitarias
URI: http://hdl.handle.net/10201/138224
DOI: 10.3389/fnut.2022.869357
Tipo de documento: info:eu-repo/semantics/article
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Descripción: ©<2022>. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Frontiers in nutrition. To access the final edited and published work see https://doi.org/10.3389/fnut.2022.869357
Aparece en las colecciones:Artículos: Ciencias Sociosanitarias

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