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10.1038/emboj.2009.163
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Pelegrin, Pablo | - |
dc.contributor.author | Surprenant, Annmarie | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular B e Inmunología | es |
dc.date.accessioned | 2024-01-25T09:33:06Z | - |
dc.date.available | 2024-01-25T09:33:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | EMBO Journal, volumen 28, nº 14, año 2009, páginas 2114-2127. | es |
dc.identifier.issn | 1460-2075 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10201/137735 | - |
dc.description | ©2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in The EMBO Journal. To access the final edited and published work see https://doi.org/10.1038/emboj.2009.163 | es |
dc.description.abstract | In acute inflammation extracellular ATP activates P2X7 ion channel receptors (P2X7R) on M1 polarized macrophages to release pro-inflammatory IL-1bvia activation of the caspase-1/Nucleotide-binding domain and Leucine-rich repeat receptor containing Pyrin domain 3 (NLRP3) inflammasome. In contrast, M2 polarized macrophages are critical to the resolution of inflammation but neither actions of P2X7R on these macrophages, nor mechanisms by which macrophages switch from pro-inflammatory to anti-inflammatory phenotypes, are known. Here we investigated extracellular ATP signaling over a dynamic macrophage polarity gradient from M1 through M2 phenotypes. In macrophages polarized towards, but not at, M2 phenotype, where intracellular IL-1b remains high and the inflammasome is intact, P2X7R activation selectively uncouples to the NLRP3-inflammasome activation but not to upstream ion channel activation. In these intermediate M1/M2 polarized macrophages, extracellular ATP now acts via its pyrophosphate chains, independently of other purine receptors, to inhibit IL-1b release by other stimuli via two independent mechanisms: inhibition of ROS production and trapping of the inflammasome complex via intracellular clustering of actin filaments. | es |
dc.format | application/pdf | es |
dc.format.extent | 46 | es |
dc.language | eng | es |
dc.publisher | EMBO Press | es |
dc.relation | Wellcome Trust | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Macrófagos | es |
dc.subject | NLRP3 | es |
dc.subject | Inflammasoma | es |
dc.subject | Inflamación | es |
dc.subject | Caspasa-1 | es |
dc.subject.other | CDU::6 - Ciencias aplicadas | es |
dc.title | Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.embopress.org/doi/full/10.1038/emboj.2009.163?pubCode=cgi | es |
dc.identifier.doi | 10.1038/emboj.2009.163 | - |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
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2009 EMBO J.pdf | Versión aceptada del artículo | 19,7 MB | Adobe PDF | Visualizar/Abrir |
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