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10.1006/cyto.2001.0949
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Título: | Interleukin-1β isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines |
Fecha de publicación: | 2001 |
Editorial: | Elsevier |
Cita bibliográfica: | Cytokine, volumen 16, nº 2, año 2001, páginas 67-72. |
ISSN: | 1043-4666 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas |
Palabras clave: | Peces Interleucina-1 Macrófagos Filogenia |
Resumen: | The gilthead seabream IL-1β gene consists of five exons/four introns. The complete coding sequence contains a 102 bp 5’ untraslated region (UTR), a single open reading frame of a 762 bp which translates into a 253 amino acid molecule, and a 407 bp 3’UTR with a polyadenilation signal 14 nucleotides upstream of the poly(A)tail. The seabream sequence has highest degree of nucleotide (61.7%) and amino acid (53%) identity with the trout IL-1β sequences. The IL-1β message was detected by RT-PCR in head-kidney, blood, spleen, liver, gill and peritoneal exudate of both non-infected and Vibrio anguillarum-challenged fish. More importantly, IL-1β was highly expressed by purified macrophage monolayers and was up-regulated by lipopolysaccharide and lymphocyte-derived macrophage-activating factor stimulation. |
Autor/es principal/es: | Pelegrin, Pablo García-Castillo, Jesús Mulero, Victoriano Meseguer, José |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular B e Inmunología |
Versión del editor: | https://www.sciencedirect.com/science/article/pii/S1043466601909494?via%3Dihub |
URI: | http://hdl.handle.net/10201/137725 |
DOI: | 10.1006/cyto.2001.0949 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 15 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2001. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Cytokine. To access the final edited and published work see https://doi.org/10.1006/cyto.2001.0949 |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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2001 Cytokine fish IL-1.pdf | Versión aceptada del artículo | 372,8 kB | Adobe PDF | Visualizar/Abrir |
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